UniProt Accession

 GBRL2_HUMAN; P60520; O08765; Q6FG91; Q9DCP8; Q9UQF7 

Genbank Protein ID

 AB030710; AF087848; AJ010569; AF077046; CR542217; AK289788; CH471114; BC005985; BC014594; BC029601 

Genbank Nucleotide ID

 BAB21548.1; AAK20400.1; CAA09249.1; AAD27779.1; CAG47013.1; BAF82477.1; EAW95630.1; AAH05985.1; AAH14594.1; AAH29601.1 

Protein Name

 Gamma-aminobutyric acid receptor-associated protein-like 2 

Protein Synonyms/Alias

 GABA(A) receptor-associated protein-like 2; Ganglioside expression factor 2; GEF-2; General protein transport factor p16; Golgi-associated ATPase enhancer of 16 kDa; GATE-16; MAP1 light chain 3-related protein 

Gene Name

 GABARAPL2 

Gene Synonyms/Alias

 FLC3A; GEF2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
24	ESAKIRAKYPDRVPV	acetylation	[1]
24	ESAKIRAKYPDRVPV	ubiquitination	[2]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 

Functional Description

 Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy. Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. 

Sequence Annotation

 REGION 1 22 Interaction with beta-tubulin (By
 REGION 36 68 Interaction with GABRG2 (Potential).
 MOD_RES 24 24 N6-acetyllysine.
 MOD_RES 39 39 Phosphoserine.
 LIPID 116 116 Phosphatidylethanolamine amidated  

Keyword

 Acetylation; Autophagy; Complete proteome; Cytoplasmic vesicle; Golgi apparatus; Lipoprotein; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 117 AA 

Protein Sequence

Gene Ontology

 GO:0000421; C:autophagic vacuole membrane; IDA:UniProtKB.
 GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
 GO:0005829; C:cytosol; ISS:UniProtKB.
 GO:0000139; C:Golgi membrane; ISS:UniProtKB.
 GO:0051117; F:ATPase binding; ISS:UniProtKB.
 GO:0048487; F:beta-tubulin binding; ISS:UniProtKB.
 GO:0050811; F:GABA receptor binding; ISS:UniProtKB.
 GO:0008017; F:microtubule binding; NAS:UniProtKB.
 GO:0000149; F:SNARE binding; ISS:UniProtKB.
 GO:0006914; P:autophagy; NAS:UniProtKB.
 GO:0006891; P:intra-Golgi vesicle-mediated transport; ISS:UniProtKB.
 GO:1901799; P:negative regulation of proteasomal protein catabolic process; IMP:BHF-UCL.
 GO:0032781; P:positive regulation of ATPase activity; ISS:UniProtKB.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 

Interpro

 IPR004241; Atg8_ubiquitin-like. 

Pfam

 PF02991; Atg8 

SMART

  

PROSITE

  

PRINTS