UniProt Accession

 RB40A_HUMAN; Q8WXH6; O00407; Q17RQ5; Q6DK06; Q8TF06 

Genbank Protein ID

 AF132748; AF422143; AB232637; Z69733; BC074854; BC074855; BC113501; BC117232 

Genbank Nucleotide ID

 AAL75949.1; AAL60514.1; BAF02899.1; CAI41993.1; AAH74854.1; AAH74855.1; AAI13502.1; AAI17233.1 

Protein Name

 Ras-related protein Rab-40A 

Protein Synonyms/Alias

 SOCS box-containing protein RAR2A; Protein Rar-2 

Gene Name

 RAB40A 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
133	NRLHLAFKRQVPREQ	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). 

Sequence Annotation

 DOMAIN 175 228 SOCS box.
 NP_BIND 21 28 GTP (By similarity).
 NP_BIND 69 73 GTP (By similarity).
 NP_BIND 126 129 GTP (By similarity).
 MOD_RES 274 274 Cysteine methyl ester (Potential).
 LIPID 269 269 S-palmitoyl cysteine (Potential).
 LIPID 274 274 S-geranylgeranyl cysteine (By  

Keyword

 Cell membrane; Complete proteome; GTP-binding; Lipoprotein; Membrane; Methylation; Nucleotide-binding; Palmitate; Polymorphism; Prenylation; Reference proteome; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 277 AA 

Protein Sequence

Gene Ontology

 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0015031; P:protein transport; IEA:InterPro.
 GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003579; Small_GTPase_Rab_type.
 IPR001496; SOCS_C. 

Pfam

 PF00071; Ras
 PF07525; SOCS_box 

SMART

 SM00175; RAB
 SM00253; SOCS
 SM00969; SOCS_box 

PROSITE

 PS51419; RAB
 PS50225; SOCS 

PRINTS

 PR00449; RASTRNSFRMNG.