CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019909
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nicotinamide phosphoribosyltransferase 
Protein Synonyms/Alias
 NAmPRTase; Nampt; Pre-B-cell colony-enhancing factor 1 homolog; PBEF; Visfatin 
Gene Name
 Nampt 
Gene Synonyms/Alias
 Pbef1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
107GWNYILEKYDGHLPIubiquitination[1]
117GHLPIEVKAVPEGSVubiquitination[1]
174EQKKILAKYLLETSGubiquitination[1]
189NLDGLEYKLHDFGYRubiquitination[1]
216SAHLVNFKGTDTVAGubiquitination[1]
228VAGIALIKKYYGTKDubiquitination[1]
234IKKYYGTKDPVPGYSubiquitination[1]
330KVLDILGKKFPVTENubiquitination[1]
339FPVTENSKGYKLLPPubiquitination[1]
342TENSKGYKLLPPYLRubiquitination[1]
372VEGMKQKKWSIENVSubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Catalyzes the condensation of nicotinamide with 5- phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. 
Sequence Annotation
 REGION 311 313 Nicotinamide ribonucleotide binding.
 REGION 353 354 Nicotinamide ribonucleotide binding.
 BINDING 196 196 Diphosphate (By similarity).
 BINDING 219 219 Nicotinamide ribonucleotide.
 BINDING 247 247 Diphosphate (By similarity).
 BINDING 311 311 Diphosphate (By similarity).
 BINDING 384 384 Nicotinamide ribonucleotide; via amide
 BINDING 392 392 Nicotinamide ribonucleotide.  
Keyword
 3D-structure; Complete proteome; Cytoplasm; Glycosyltransferase; Pyridine nucleotide biosynthesis; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 491 AA 
Protein Sequence
MNAAAEAEFN ILLATDSYKV THYKQYPPNT SKVYSYFECR EKKTENSKVR KVKYEETVFY 60
GLQYILNKYL KGKVVTKEKI QEAKEVYREH FQDDVFNERG WNYILEKYDG HLPIEVKAVP 120
EGSVIPRGNV LFTVENTDPE CYWLTNWIET ILVQSWYPIT VATNSREQKK ILAKYLLETS 180
GNLDGLEYKL HDFGYRGVSS QETAGIGASA HLVNFKGTDT VAGIALIKKY YGTKDPVPGY 240
SVPAAEHSTI TAWGKDHEKD AFEHIVTQFS SVPVSVVSDS YDIYNACEKI WGEDLRHLIV 300
SRSTEAPLII RPDSGNPLDT VLKVLDILGK KFPVTENSKG YKLLPPYLRV IQGDGVDINT 360
LQEIVEGMKQ KKWSIENVSF GSGGALLQKL TRDLLNCSFK CSYVVTNGLG VNVFKDPVAD 420
PNKRSKKGRL SLHRTPAGNF VTLEEGKGDL EEYGHDLLHT VFKNGKVTKS YSFDEVRKNA 480
QLNIEQDVAP H 491 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0008144; F:drug binding; IEA:Compara.
 GO:0047280; F:nicotinamide phosphoribosyltransferase activity; IDA:MGI.
 GO:0004516; F:nicotinate phosphoribosyltransferase activity; IEA:InterPro.
 GO:0004514; F:nicotinate-nucleotide diphosphorylase (carboxylating) activity; IEA:InterPro.
 GO:0007049; P:cell cycle; IEA:Compara.
 GO:0007565; P:female pregnancy; IEA:Compara.
 GO:0009435; P:NAD biosynthetic process; IDA:MGI.
 GO:0048661; P:positive regulation of smooth muscle cell proliferation; IEA:Compara.
 GO:0014070; P:response to organic cyclic compound; IEA:Compara. 
Interpro
 IPR015977; Nic_PRibTrfase-like.
 IPR016471; Nicotinamide_PRibTrfase.
 IPR002638; Quinolinate_PRibosylTrfase_C. 
Pfam
 PF04095; NAPRTase 
SMART
  
PROSITE
  
PRINTS