CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012051
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Battenin 
Protein Synonyms/Alias
 Batten disease protein; Protein CLN3 
Gene Name
 CLN3 
Gene Synonyms/Alias
 BTS 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
262RTEAPESKPGSSSSLubiquitination[1, 2, 3]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 Involved in microtubule-dependent, anterograde transport of late endosomes and lysosomes. 
Sequence Annotation
 MOD_RES 12 12 Phosphoserine.
 MOD_RES 14 14 Phosphoserine.
 MOD_RES 435 435 Cysteine methyl ester (Probable).
 LIPID 435 435 S-farnesyl cysteine.
 CARBOHYD 71 71 N-linked (GlcNAc...).
 CARBOHYD 85 85 N-linked (GlcNAc...).
 CARBOHYD 310 310 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Complete proteome; Disease mutation; Endosome; Glycoprotein; Lipoprotein; Lysosome; Membrane; Methylation; Neurodegeneration; Neuronal ceroid lipofuscinosis; Phosphoprotein; Prenylation; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 438 AA 
Protein Sequence
MGGCAGSRRR FSDSEGEETV PEPRLPLLDH QGAHWKNAVG FWLLGLCNNF SYVVMLSAAH 60
DILSHKRTSG NQSHVDPGPT PIPHNSSSRF DCNSVSTAAV LLADILPTLV IKLLAPLGLH 120
LLPYSPRVLV SGICAAGSFV LVAFSHSVGT SLCGVVFASI SSGLGEVTFL SLTAFYPRAV 180
ISWWSSGTGG AGLLGALSYL GLTQAGLSPQ QTLLSMLGIP ALLLASYFLL LTSPEAQDPG 240
GEEEAESAAR QPLIRTEAPE SKPGSSSSLS LRERWTVFKG LLWYIVPLVV VYFAEYFINQ 300
GLFELLFFWN TSLSHAQQYR WYQMLYQAGV FASRSSLRCC RIRFTWALAL LQCLNLVFLL 360
ADVWFGFLPS IYLVFLIILY EGLLGGAAYV NTFHNIALET SDEHREFAMA ATCISDTLGI 420
SLSGLLALPL HDFLCQLS 438 
Gene Ontology
 GO:0005776; C:autophagic vacuole; ISS:UniProtKB.
 GO:0005901; C:caveola; IDA:UniProtKB.
 GO:0005769; C:early endosome; IDA:UniProtKB.
 GO:0000139; C:Golgi membrane; IDA:UniProtKB.
 GO:0005795; C:Golgi stack; IDA:UniProtKB.
 GO:0030176; C:integral to endoplasmic reticulum membrane; IDA:UniProtKB.
 GO:0005770; C:late endosome; IDA:UniProtKB.
 GO:0005765; C:lysosomal membrane; IDA:UniProtKB.
 GO:0005739; C:mitochondrion; TAS:ProtInc.
 GO:0043005; C:neuron projection; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0008021; C:synaptic vesicle; IDA:UniProtKB.
 GO:0005802; C:trans-Golgi network; IDA:UniProtKB.
 GO:0051082; F:unfolded protein binding; TAS:ProtInc.
 GO:0042987; P:amyloid precursor protein catabolic process; IDA:UniProtKB.
 GO:0015809; P:arginine transport; IDA:UniProtKB.
 GO:0008306; P:associative learning; ISS:UniProtKB.
 GO:0000046; P:autophagic vacuole fusion; ISS:UniProtKB.
 GO:0008219; P:cell death; IEA:UniProtKB-KW.
 GO:0006520; P:cellular amino acid metabolic process; ISS:UniProtKB.
 GO:0051480; P:cytosolic calcium ion homeostasis; ISS:UniProtKB.
 GO:0006681; P:galactosylceramide metabolic process; IMP:UniProtKB.
 GO:0001575; P:globoside metabolic process; IMP:UniProtKB.
 GO:0006678; P:glucosylceramide metabolic process; IMP:UniProtKB.
 GO:0035235; P:ionotropic glutamate receptor signaling pathway; ISS:UniProtKB.
 GO:0007042; P:lysosomal lumen acidification; IMP:UniProtKB.
 GO:0035752; P:lysosomal lumen pH elevation; IDA:UniProtKB.
 GO:0043086; P:negative regulation of catalytic activity; ISS:UniProtKB.
 GO:0016242; P:negative regulation of macroautophagy; ISS:UniProtKB.
 GO:0043524; P:negative regulation of neuron apoptotic process; ISS:UniProtKB.
 GO:0045861; P:negative regulation of proteolysis; ISS:UniProtKB.
 GO:0050885; P:neuromuscular process controlling balance; ISS:UniProtKB.
 GO:0042133; P:neurotransmitter metabolic process; ISS:UniProtKB.
 GO:0030163; P:protein catabolic process; NAS:UniProtKB.
 GO:0006457; P:protein folding; TAS:ProtInc.
 GO:0016485; P:protein processing; ISS:UniProtKB.
 GO:0006898; P:receptor-mediated endocytosis; IMP:UniProtKB.
 GO:0001508; P:regulation of action potential; ISS:UniProtKB.
 GO:0006684; P:sphingomyelin metabolic process; IMP:UniProtKB.
 GO:0007034; P:vacuolar transport; IBA:RefGenome.
 GO:0047496; P:vesicle transport along microtubule; IMP:UniProtKB. 
Interpro
 IPR003492; Battenin_disease_Cln3.
 IPR018460; Battenin_disease_Cln3_subgr.
 IPR016196; MFS_dom_general_subst_transpt. 
Pfam
 PF02487; CLN3 
SMART
  
PROSITE
  
PRINTS
 PR01315; BATTENIN.