UniProt Accession

 PAIRB_RAT; Q6AXS5; Q8VHU3 

Genbank Protein ID

 AF388527; BC079337 

Genbank Nucleotide ID

 AAL57768.1; AAH79337.1 

Protein Name

 Plasminogen activator inhibitor 1 RNA-binding protein 

Protein Synonyms/Alias

 PAI1 RNA-binding protein 1; PAI-RBP1; RDA288; SERPINE1 mRNA-binding protein 1; Plasminogen activator inhibitor 1 RNA-binding protein, N-terminally processed 

Gene Name

 Serbp1 

Gene Synonyms/Alias

 Pairbp1; Rda288 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
68	TNSNAAGKQLRKESQ	acetylation	[1]
102	TQPPVALKKEGIRRV	acetylation	[1]
122	QQLQGDGKIIDRRPE	acetylation	[1]
140	PRERRFEKPLEEKGE	acetylation	[1]
211	FSHYSGLKHEDKRGG	acetylation	[1]
215	SGLKHEDKRGGSGSH	acetylation	[1]
280	ENEVEEVKEEGPKEM	acetylation	[1]
302	IQNKDRAKVEFNIRK	acetylation	[1]
319	EGADGQWKKGFVLHK	acetylation	[1]
328	GFVLHKSKSEEAHAE	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 May play a role in the regulation of mRNA stability. Binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay (By similarity). 

Sequence Annotation

 MOD_RES 25 25 Phosphoserine (By similarity).
 MOD_RES 68 68 N6-acetyllysine (By similarity).
 MOD_RES 122 122 N6-acetyllysine (By similarity).
 MOD_RES 140 140 N6-acetyllysine (By similarity).
 MOD_RES 211 211 N6-acetyllysine (By similarity).
 MOD_RES 234 234 Phosphoserine (By similarity).
 MOD_RES 244 244 Phosphotyrosine (By similarity).
 MOD_RES 252 252 Phosphoserine (By similarity).
 MOD_RES 329 329 Phosphoserine (By similarity).
 MOD_RES 390 390 Phosphoserine (By similarity).
 MOD_RES 391 391 Phosphoserine (By similarity).
 MOD_RES 393 393 Phosphoserine (By similarity).  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 407 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:RGD.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IDA:RGD.
 GO:0003730; F:mRNA 3'-UTR binding; ISS:HGNC.
 GO:0042981; P:regulation of apoptotic process; IDA:RGD. 

Interpro

 IPR006861; HABP4_PAIRBP1-bd.
 IPR027205; SERBP1. 

Pfam

 PF04774; HABP4_PAI-RBP1 

SMART

  

PROSITE

  

PRINTS