CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034208
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Ubiquitin-like modifier-activating enzyme 6 
Protein Synonyms/Alias
  
Gene Name
 Uba6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
472TDPDLIEKSNLNRQFubiquitination[1]
513KIDAHLNKVCPATESacetylation[2, 3]
513KIDAHLNKVCPATESubiquitination[1]
621FESSFSHKPSLFNKFubiquitination[1]
698FPLETRLKDGSLFWQacetylation[4]
708SLFWQSPKRPPSPIKubiquitination[1]
805EEALSSNKATKSDLQubiquitination[1]
808LSSNKATKSDLQMTVubiquitination[1]
851IEPADRFKTKRIAGKubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1022 AA 
Protein Sequence
MTTESLEIDD GLYSRQRYVL GDTAMQKMAK SCVFLSGMGG LGVEIAKNLV LAGIKALTIH 60
DTKKCQAWDL GTNFFLCEDD VVNERNRAEA VLHRIAELNP YVQVSSSSAP LDETTDLSFL 120
EKYQCVVLTE IKLTLQKKIN NFCHSHCPPI KFISADVHGI WSRLFCDFGD EFEVSDTTGE 180
EPKEIFISNI TQANPGIVTC LESHPHKLET GQFLTFREIH GMTGLNGSVQ QITVISPFSF 240
SIGDTTKLDP YLHGGIAVQV KTPKTFCFEP LESQIKHPRC LIADFSKPEA PLEIHLAMLA 300
LDQFQENYNR KPNIRCQQDS DELLKLTVSI NETLEEKPEV NADIVHWLSW TAQGFLPPLA 360
AAVGGVASQE VLKAVTGKFS PLCQWLYLEA ADTVESLGNP GHEEFLPRGD RYDAIRACIG 420
NTLCQKLQNL NIFLVGCGAI GCEMLKNFAL LGVGTGREKG MVTVTDPDLI EKSNLNRQFL 480
FRPHHIQKPK SYTAAEATLK INPQLKIDAH LNKVCPATES IYSDEFYTKQ DIIITALDNV 540
EARRYVDSRC LANLRPLLDS GTMGTKGHTE IIVPQLTESY NSHRDPPEEE IPFCTLKSFP 600
AAIEHTIQWA RDKFESSFSH KPSLFNKFWQ AYPSAEDVLQ KIQNGQSLEG CFQVIKLLSR 660
RPRIWSQCVE LARLKFEKYF NHKALQLLHC FPLETRLKDG SLFWQSPKRP PSPIKFDLNE 720
PLHLSFLQSA AKLYATVYCI PFSEKDLSVN SLMDILSEVK IEEFKPSNKV VQTDETARKP 780
DHVPVSSEDE RNAVFQLEEA LSSNKATKSD LQMTVLSFEK DDDRNGHIDF ITAASNLRAK 840
MYSIEPADRF KTKRIAGKII PAIATSTAAV SGLVALEMIK VAGGYPFDAY KNCFLNLAIP 900
IIVFTETSEV RKTEIRNGIS FTIWDRWTVH GKEDFTLSDF INAVKENYGI EPTMVVQGVK 960
MLYVPVMPGH AKRLKLTMHK LVKPSTEKKY VDLTVSFAPD ADGDEDLPGP PVRYYFSHDT 1020
NE 1022 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0019780; F:FAT10 activating enzyme activity; IEA:Compara.
 GO:0006464; P:cellular protein modification process; IEA:InterPro.
 GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:Compara. 
Interpro
 IPR009036; Molybdenum_cofac_synth_MoeB.
 IPR016040; NAD(P)-bd_dom.
 IPR000594; ThiF_NAD_FAD-bd.
 IPR018965; Ub-activating_enz_e1_C.
 IPR023280; Ub-like_act_enz_cat_cys_dom.
 IPR000127; UBact_repeat.
 IPR019572; Ubiquitin-activating_enzyme.
 IPR018075; UBQ-activ_enz_E1.
 IPR000011; UBQ/SUMO-activ_enz_E1-like. 
Pfam
 PF00899; ThiF
 PF09358; UBA_e1_C
 PF10585; UBA_e1_thiolCys
 PF02134; UBACT 
SMART
 SM00985; UBA_e1_C 
PROSITE
  
PRINTS
 PR01849; UBIQUITINACT.