| Tag | Content |
|---|
| CPLM ID | CPLM-018187 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Cullin-7 |
Protein Synonyms/Alias | CUL-7; p185; p193 |
Gene Name | Cul7 |
Gene Synonyms/Alias | Kiaa0076 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 897 | NSIKSVNKELNTVNV | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Component of a probable SCF-like E3 ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. In complex with FBXW8, mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain (By similarity). Probably plays a role in the degradation of proteins involved in endothelial proliferation and/or differentiation. |
Sequence Annotation | DOMAIN 793 972 DOC.
REGION 349 449 Interaction with TP53 (By similarity).
CROSSLNK 1567 1567 Glycyl lysine isopeptide (Lys-Gly) |
Keyword | Alternative splicing; Complete proteome; Cytoplasm; Golgi apparatus; Isopeptide bond; Reference proteome; Ubl conjugation; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1689 AA |
Protein Sequence | MVGELRYREF RVPLGPGLHA YPDELIRQRV GHNGHPEYQI RWLILRRGDD GDRDSTVDCK 60
AEHILLWMSD DEIYANCHKM LGENGQVIAP SRESTEAGAL DKSVLGEMET DVKSLIQRAL 120
RQLEECVGTV PPAPLLHTVH VLSAYASIEP LTGIFKDRRV VNLLMHMLSS PDYQIRWSAG 180
RMIQALSSHD AGTRTQILLS LSQQEAIEKH LDFDSRCALL ALFAQATLTE HPMSFEGVQL 240
PQVPGRLLFS LVKRYLHVTF LLDRLNGDAG DQGAQNNFIP EELNVGRGRL ELEFSMAMGT 300
LISELVQAMR WDGASSRPES SSSSTFQPRP AQFRPYTQRF RRSRRFRPRA SFASFNTYAL 360
YVRDTLRPGM RVRMLENYEE IAAGDEGQFR QSNDGVPPAQ VLWDSTGHTY WVHWHMLEIL 420
GFEEDIEDVI DIEELQELGA NGALSIVPPS QRWKPITQLF AEPYVVPEEE DREESENLTQ 480
AEWWELLFFI RQLSEAERLH IVDLLQDHLE EERVLDYDML PELTVPVDLA QDLLLSLPQQ 540
LEDSALRDLF SCSVYRKYGP EVLVGHLSYP FVPGAQPNLF GANEESEAKD PPLQSASPAL 600
QRLVESLGPE GEVLVELEQA LGSEAPQETE VKSCLLQLQE QPQPFLALMR SLDTSASNKT 660
LHLTVLRILM QLVNFPEALL LPWHEAMDAC VTCLRSPNTD REVLQELIFF LHRLTTTSRD 720
YAVILNQLGA RDAISKVLEK HRGKLELAQE LRDMVSKCEK HAHLYRKLTT NILGGCIQMV 780
LGQIEDHRRT HRPIQIPFFD VFLRYLCQGS SEEMKKNRYW EKVEVSSNPQ RASRLTDRNP 840
KTYWESSGRA GSHFITLHMR PGVIIRQLTL LVAGEDSSYM PAWVVVCGGN SIKSVNKELN 900
TVNVMPSASR VTLLENLTRF WPIIQIRIKR CQQGGINTRI RGLEVLGPKP TFWPVFREQL 960
CRHTRLFYMV RAQAWSQDIA EDRRSLLHLS SRLNGALRHE QNFAERFLPD MEAAQALSKT 1020
CWEALVSPLV QNITSPDEDS TSSLGWLLDQ YLGCREAAYN PQSRAAAFSS RVRRLTHLLV 1080
HVEPREAAPP VVAIPRSKGR NRIHDWSYLI TRGLPSSIMK NLTRCWRSVV EEQMNKFLTA 1140
SWKDDDFVPR YCERYYVLQK SSSELFGPRA AFLLAMRNGC ADAVLRLPFL RAAHVSEQFA 1200
RHIDQRIQGS RMGGARGMEM LAQLQRCLES VLIFSPLEIA TTFEHYYQHY MADRLLSVGS 1260
SWLEGAVLEQ IGPCFPSRLP QQMLQSLNVS EELQRQFHVY QLQQLDQELL KLEDTEKKIQ 1320
VAHEDSGRED KSKKEEAIGE AAAVAMAEEE DQGKKEEGEE EGEGEDEEEE RYYKGTMPEV 1380
CVLVVTPRFW PVASVCQMLN PATCLPAYLR GTINHYTNFY SKSQSRSSLE KEPQRRLQWT 1440
WQGRAEVQFG GQILHVSTVQ MWLLLHLNNQ KEVSVESLQA ISELPPDVLH RAIGPLTSSR 1500
GPLDLQEQKN VPGGVLKIRD DSEEPRPRRG NVWLIPPQTY LQAEAEEGRN MEKRRNLLNC 1560
LVVRILKAHG DEGLHVDRLV YLVLEAWEKG PCPARGLVSS LGRGATCRSS DVLSCILHLL 1620
VKGTLRRHDD RPQVLYYAVP VTVMEPHMES LNPGSAGPNP PLTFHTLQIR SRGVPYASCT 1680
DNHTFSTFR 1689 |
Gene Ontology | GO:0031467; C:Cul7-RING ubiquitin ligase complex; IDA:UniProtKB. GO:0005794; C:Golgi apparatus; ISS:UniProtKB. GO:0005634; C:nucleus; IEA:Compara. GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB. GO:0007049; P:cell cycle; NAS:UniProtKB. GO:0007030; P:Golgi organization; ISS:UniProtKB. GO:0050775; P:positive regulation of dendrite morphogenesis; ISS:UniProtKB. GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway. GO:0045601; P:regulation of endothelial cell differentiation; NAS:UniProtKB. GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro. GO:0001570; P:vasculogenesis; IMP:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |