UniProt Accession

 TDH_ECOLI; P07913; Q2M7T0 

Genbank Protein ID

 X06690; U00039; U00096; AP009048 

Genbank Nucleotide ID

 CAA29884.1; AAB18593.1; AAC76640.1; BAE77676.1 

Protein Name

 L-threonine 3-dehydrogenase 

Protein Synonyms/Alias

  

Gene Name

 tdh 

Gene Synonyms/Alias

 b3616; JW3591 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
77	VGIGQEVKGFKIGDR	acetylation	[1]
80	GQEVKGFKIGDRVSG	acetylation	[2]
279	DWTKVIFKGLFIKGI	acetylation	[1]
284	IFKGLFIKGIYGREM	acetylation	[1]
323	FSIDDFQKGFDAMRS	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618]
 [2] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111] 

Functional Description

  

Sequence Annotation

 METAL 38 38 Zinc 1; catalytic.
 METAL 63 63 Zinc 1; catalytic (By similarity).
 METAL 93 93 Zinc 2 (By similarity).
 METAL 96 96 Zinc 2 (By similarity).
 METAL 99 99 Zinc 2 (By similarity).
 METAL 107 107 Zinc 2 (By similarity).
 METAL 148 148 Zinc 1; catalytic (By similarity).  

Keyword

 Cobalt; Complete proteome; Cytoplasm; Direct protein sequencing; Manganese; Metal-binding; NAD; Oxidoreductase; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 341 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0046870; F:cadmium ion binding; IDA:EcoliWiki.
 GO:0008743; F:L-threonine 3-dehydrogenase activity; IDA:EcoliWiki.
 GO:0030145; F:manganese ion binding; IDA:EcoliWiki.
 GO:0008270; F:zinc ion binding; IDA:EcoliWiki.
 GO:0006565; P:L-serine catabolic process; IGI:EcoliWiki.
 GO:0019518; P:L-threonine catabolic process to glycine; IEA:UniProtKB-UniPathway.
 GO:0006567; P:threonine catabolic process; IMP:EcoCyc. 

Interpro

 IPR013149; ADH_C.
 IPR013154; ADH_GroES-like.
 IPR002085; ADH_SF_Zn-type.
 IPR002328; ADH_Zn_CS.
 IPR011032; GroES-like.
 IPR004627; L-Threonine_3-DHase.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF08240; ADH_N
 PF00107; ADH_zinc_N 

SMART

  

PROSITE

 PS00059; ADH_ZINC 

PRINTS