CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000522
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Glyoxal reductase 
Protein Synonyms/Alias
 GR; Methylglyoxal reductase 
Gene Name
 yvgN 
Gene Synonyms/Alias
 BSU33400 
Created Date
 July 27, 2013 
Organism
 Bacillus subtilis (strain 168) 
NCBI Taxa ID
 224308 
Lysine Modification
Position
Peptide
Type
References
6**MPTSLKDTVKLHNacetylation[1]
Reference
 [1] The acetylproteome of Gram-positive model bacterium Bacillus subtilis.
 Kim D, Yu BJ, Kim JA, Lee YJ, Choi SG, Kang S, Pan JG.
 Proteomics. 2013 May;13(10-11):1726-36. [PMID: 23468065] 
Functional Description
 Reduces glyoxal and methylglyoxal. Is not involved in the vitamin B6 biosynthesis. 
Sequence Annotation
 NP_BIND 190 242 NADP (By similarity).
 ACT_SITE 54 54 Proton donor (By similarity).
 BINDING 112 112 Substrate (By similarity).  
Keyword
 3D-structure; Complete proteome; Direct protein sequencing; NADP; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 276 AA 
Protein Sequence
MPTSLKDTVK LHNGVEMPWF GLGVFKVENG NEATESVKAA IKNGYRSIDT AAIYKNEEGV 60
GIGIKESGVA REELFITSKV WNEDQGYETT LAAFEKSLER LQLDYLDLYL IHWPGKDKYK 120
DTWRALEKLY KDGKIRAIGV SNFQVHHLEE LLKDAEIKPM VNQVEFHPRL TQKELRDYCK 180
GQGIQLEAWS PLMQGQLLDN EVLTQIAEKH NKSVAQVILR WDLQHGVVTI PKSIKEHRII 240
ENADIFDFEL SQEDMDKIDA LNKDERVGPN PDELLF 276 
Gene Ontology
 GO:0043892; F:methylglyoxal reductase (NADPH-dependent) activity; IEA:EC. 
Interpro
 IPR001395; Aldo/ket_red.
 IPR018170; Aldo/ket_reductase_CS.
 IPR020471; Aldo/keto_reductase_subgr.
 IPR023210; NADP_OxRdtase_dom. 
Pfam
 PF00248; Aldo_ket_red 
SMART
  
PROSITE
 PS00798; ALDOKETO_REDUCTASE_1
 PS00062; ALDOKETO_REDUCTASE_2
 PS00063; ALDOKETO_REDUCTASE_3 
PRINTS
 PR00069; ALDKETRDTASE.