| Tag | Content |
|---|
| CPLM ID | CPLM-020131 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Rhotekin |
Protein Synonyms/Alias | |
Gene Name | RTKN |
Gene Synonyms/Alias | RTKN1 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 93 | MGELQRRKEAQVLGK | ubiquitination | [1] | | 100 | KEAQVLGKTSRRPSD | ubiquitination | [1] | | 133 | LRIPLMWKDTEYFKN | ubiquitination | [1] | | 139 | WKDTEYFKNKGDLHR | ubiquitination | [1] | | 216 | GPKRLATKLSSSLGR | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | Mediates Rho signaling to activate NF-kappa-B and may confer increased resistance to apoptosis to cells in gastric tumorigenesis. May play a novel role in the organization of septin structures. |
Sequence Annotation | REPEAT 36 99 REM.
DOMAIN 309 416 PH.
MOD_RES 106 106 Phosphoserine (By similarity).
MOD_RES 232 232 Phosphoserine.
MOD_RES 520 520 Phosphoserine (By similarity).
MOD_RES 543 543 Phosphoserine. |
Keyword | Alternative splicing; Apoptosis; Complete proteome; GTP-binding; Nucleotide-binding; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 563 AA |
Protein Sequence | MFSRNHRSRV TVARGSALEM EFKRGRFRLS LFSDLPEDTE LQRKLDHEIR MREGACKLLA 60
ACSQREQALE ATKSLLVCNS RILSYMGELQ RRKEAQVLGK TSRRPSDSGP PAERSPCRGR 120
VCISDLRIPL MWKDTEYFKN KGDLHRWAVF LLLQLGEHIQ DTEMILVDRT LTDISFQSNV 180
LFAEAGPDFE LRLELYGACV EEEGALTGGP KRLATKLSSS LGRSSGRRVR ASLDSAGGSG 240
SSPILLPTPV VGGPRYHLLA HTTLTLAAVQ DGFRTHDLTL ASHEENPAWL PLYGSVCCRL 300
AAQPLCMTQP TASGTLRVQQ AGEMQNWAQV HGVLKGTNLF CYRQPEDADT GEEPLLTIAV 360
NKETRVRAGE LDQALGRPFT LSISNQYGDD EVTHTLQTES REALQSWMEA LWQLFFDMSQ 420
WKQCCDEIMK IETPAPRKPP QALAKQGSLY HEMAIEPLDD IAAVTDILTQ REGARLETPP 480
PWLAMFTDQP ALPNPCSPAS VAPAPDWTHP LPWGRPRTFS LDAVPPDHSP RARSVAPLPP 540
QRSPRTRGLC SKGQPRTWLQ SPV 563 |
Gene Ontology | GO:0005525; F:GTP binding; IEA:UniProtKB-KW. GO:0017049; F:GTP-Rho binding; IDA:UniProtKB. GO:0005095; F:GTPase inhibitor activity; IDA:UniProtKB. GO:0005543; F:phospholipid binding; IEA:InterPro. GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. GO:0007266; P:Rho protein signal transduction; IDA:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |