CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041401
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Poly(A) polymerase alpha 
Protein Synonyms/Alias
  
Gene Name
 PAPOLA 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
81NRILILGKLNNLVKEubiquitination[1]
97IREISESKNLPQSVIubiquitination[1]
150FFTSFYDKLKLQEEVubiquitination[2, 3]
152TSFYDKLKLQEEVKDubiquitination[1]
158LKLQEEVKDLRAVEEacetylation[4]
158LKLQEEVKDLRAVEEubiquitination[1, 3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 177 AA 
Protein Sequence
MPFPVTTQGS QQTQPPQKHY GITSPISLAA PKETDCVLTQ KLIETLKPFG VFEEEEELQR 60
SNDLEYLIDN CFINRILILG KLNNLVKEWI REISESKNLP QSVIENVGGK IFTFGSYRLG 120
VHTKGADIDA LCVAPRHVDR SDFFTSFYDK LKLQEEVKDL RAVEEAFVPV IKLCFDG 177 
Gene Ontology
 GO:0004652; F:polynucleotide adenylyltransferase activity; IEA:InterPro.
 GO:0043631; P:RNA polyadenylation; IEA:InterPro. 
Interpro
 IPR002934; Nucleotidyltransferase.
 IPR007012; PolA_pol_cen_dom. 
Pfam
 PF01909; NTP_transf_2
 PF04928; PAP_central 
SMART
  
PROSITE
  
PRINTS