CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023879
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Low-density lipoprotein receptor-related protein 12 
Protein Synonyms/Alias
 LRP-12; Suppressor of tumorigenicity 7 protein 
Gene Name
 LRP12 
Gene Synonyms/Alias
 ST7 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
160RLAYFSGKSEEPNCAubiquitination[1]
228QCLSRFTKVYTCLPEubiquitination[1]
305ILRFTDFKLDGTGYGubiquitination[1]
327GLEENPHKLLRVLTAubiquitination[1]
358RVHFCADKVNAARGFubiquitination[1]
415TNCTMCQKEEFPCSRubiquitination[1]
678VAAPLPQKVPPTTAVubiquitination[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
 Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor. 
Sequence Annotation
 DOMAIN 47 159 CUB 1.
 DOMAIN 165 201 LDL-receptor class A 1.
 DOMAIN 214 255 LDL-receptor class A 2.
 DOMAIN 259 372 CUB 2.
 DOMAIN 374 411 LDL-receptor class A 3.
 DOMAIN 412 449 LDL-receptor class A 4.
 DOMAIN 450 486 LDL-receptor class A 5.
 CARBOHYD 75 75 N-linked (GlcNAc...) (Potential).
 CARBOHYD 146 146 N-linked (GlcNAc...) (Potential).
 CARBOHYD 284 284 N-linked (GlcNAc...) (Potential).
 CARBOHYD 366 366 N-linked (GlcNAc...) (Potential).
 CARBOHYD 409 409 N-linked (GlcNAc...) (Potential).
 CARBOHYD 441 441 N-linked (GlcNAc...) (Potential).
 DISULFID 47 76 By similarity.
 DISULFID 103 122 By similarity.
 DISULFID 166 178 By similarity.
 DISULFID 173 191 By similarity.
 DISULFID 185 200 By similarity.
 DISULFID 215 232 By similarity.
 DISULFID 222 245 By similarity.
 DISULFID 239 254 By similarity.
 DISULFID 259 285 By similarity.
 DISULFID 375 388 By similarity.
 DISULFID 382 401 By similarity.
 DISULFID 395 410 By similarity.
 DISULFID 413 426 By similarity.
 DISULFID 420 439 By similarity.
 DISULFID 433 448 By similarity.
 DISULFID 451 463 By similarity.
 DISULFID 458 476 By similarity.
 DISULFID 470 485 By similarity.  
Keyword
 Alternative splicing; Coated pit; Complete proteome; Disulfide bond; Endocytosis; Glycoprotein; Membrane; Polymorphism; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 859 AA 
Protein Sequence
MACRWSTKES PRWRSALLLL FLAGVYGNGA LAEHSENVHI SGVSTACGET PEQIRAPSGI 60
ITSPGWPSEY PAKINCSWFI RANPGEIITI SFQDFDIQGS RRCNLDWLTI ETYKNIESYR 120
ACGSTIPPPY ISSQDHIWIR FHSDDNISRK GFRLAYFSGK SEEPNCACDQ FRCGNGKCIP 180
EAWKCNNMDE CGDSSDEEIC AKEANPPTAA AFQPCAYNQF QCLSRFTKVY TCLPESLKCD 240
GNIDCLDLGD EIDCDVPTCG QWLKYFYGTF NSPNYPDFYP PGSNCTWLID TGDHRKVILR 300
FTDFKLDGTG YGDYVKIYDG LEENPHKLLR VLTAFDSHAP LTVVSSSGQI RVHFCADKVN 360
AARGFNATYQ VDGFCLPWEI PCGGNWGCYT EQQRCDGYWH CPNGRDETNC TMCQKEEFPC 420
SRNGVCYPRS DRCNYQNHCP NGSDEKNCFF CQPGNFHCKN NRCVFESWVC DSQDDCGDGS 480
DEENCPVIVP TRVITAAVIG SLICGLLLVI ALGCTCKLYS LRMFERRSFE TQLSRVEAEL 540
LRREAPPSYG QLIAQGLIPP VEDFPVCSPN QASVLENLRL AVRSQLGFTS VRLPMAGRSS 600
NIWNRIFNFA RSRHSGSLAL VSADGDEVVP SQSTSREPER NHTHRSLFSV ESDDTDTENE 660
RRDMAGASGG VAAPLPQKVP PTTAVEATVG ACASSSTQST RGGHADNGRD VTSVEPPSVS 720
PARHQLTSAL SRMTQGLRWV RFTLGRSSSL SQNQSPLRQL DNGVSGREDD DDVEMLIPIS 780
DGSSDFDVND CSRPLLDLAS DQGQGLRQPY NATNPGVRPS NRDGPCERCG IVHTAQIPDT 840
CLEVTLKNET SDDEALLLC 859 
Gene Ontology
 GO:0005905; C:coated pit; IEA:UniProtKB-SubCell.
 GO:0005887; C:integral to plasma membrane; IDA:UniProtKB.
 GO:0005041; F:low-density lipoprotein receptor activity; NAS:UniProtKB.
 GO:0040008; P:regulation of growth; NAS:UniProtKB.
 GO:0007165; P:signal transduction; NAS:UniProtKB. 
Interpro
 IPR000859; CUB_dom.
 IPR023415; LDLR_class-A_CS.
 IPR002172; LDrepeatLR_classA_rpt. 
Pfam
 PF00431; CUB
 PF00057; Ldl_recept_a 
SMART
 SM00042; CUB
 SM00192; LDLa 
PROSITE
 PS01180; CUB
 PS01209; LDLRA_1
 PS50068; LDLRA_2 
PRINTS