CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006892
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Hsp70 nucleotide exchange factor FES1 
Protein Synonyms/Alias
 Factor exchange for SSA1 protein 1 
Gene Name
 FES1 
Gene Synonyms/Alias
 YBR101C; YBR0830 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
16IANSQGDKEAMARAGubiquitination[1]
28RAGQPDPKLLQQLFGubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Involved in protein translation, propagation of [PSI+] prions, and polyamine tolerance. Functions as a nucleotide exchange factor (NEF), which accelerates the release of ADP, for the cytosolic Hsp70 chaperone SSA1 and the ribosome-associated Hsp70 chaperone SSB1. Required for fully efficient Hsp70-mediated folding of proteins. 
Sequence Annotation
 REPEAT 13 57 ARM 1.
 REPEAT 76 116 ARM 2.
 REPEAT 120 161 ARM 3.
 REPEAT 164 205 ARM 4.
 REPEAT 211 251 ARM 5.
 REPEAT 253 290 ARM 6.
 MOD_RES 12 12 Phosphoserine.  
Keyword
 Complete proteome; Cytoplasm; Phosphoprotein; Reference proteome; Repeat; Translation regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 290 AA 
Protein Sequence
MEKLLQWSIA NSQGDKEAMA RAGQPDPKLL QQLFGGGGPD DPTLMKESMA VIMNPEVDLE 60
TKLVAFDNFE MLIENLDNAN NIENLKLWEP LLDVLVQTKD EELRAAALSI IGTAVQNNLD 120
SQNNFMKYDN GLRSLIEIAS DKTKPLDVRT KAFYALSNLI RNHKDISEKF FKLNGLDCIA 180
PVLSDNTAKP KLKMRAIALL TAYLSSVKID ENIISVLRKD GVIESTIECL SDESNLNIID 240
RVLSFLSHLI SSGIKFNEQE LHKLNEGYKH IEPLKDRLNE DDYLAVKYVL 290 
Gene Ontology
 GO:0022626; C:cytosolic ribosome; IPI:SGD.
 GO:0000774; F:adenyl-nucleotide exchange factor activity; IDA:SGD.
 GO:0002181; P:cytoplasmic translation; IPI:SGD.
 GO:0006417; P:regulation of translation; IEA:UniProtKB-KW. 
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR013918; Nucleotide_exch_fac_Fes1. 
Pfam
 PF08609; Fes1 
SMART
  
PROSITE
 PS50176; ARM_REPEAT 
PRINTS