UniProt Accession

 KAPC_YEAST; P05986; D6VX33 

Genbank Protein ID

 M17074; Z26878; Z28166; M81697; BK006944 

Genbank Nucleotide ID

 AAA35166.1; CAA81521.1; CAA82008.1; AAA34791.1; DAA08999.1 

Protein Name

 cAMP-dependent protein kinase type 3 

Protein Synonyms/Alias

 PKA 3 

Gene Name

 TPK3 

Gene Synonyms/Alias

 PKA3; YKL166C; YKL630 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
82	QYRDTSGKYSLSDFQ	acetylation	[1]
213	DIIYRDLKPENILLD	ubiquitination	[2]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

  

Sequence Annotation

 DOMAIN 88 342 Protein kinase.
 DOMAIN 343 398 AGC-kinase C-terminal.
 NP_BIND 94 102 ATP (By similarity).
 ACT_SITE 211 211 Proton acceptor (By similarity).
 BINDING 117 117 ATP (By similarity).
 MOD_RES 55 55 Phosphoserine.  

Keyword

 ATP-binding; cAMP; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 398 AA 

Protein Sequence

Gene Ontology

 GO:0005952; C:cAMP-dependent protein kinase complex; IGI:SGD.
 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004691; F:cAMP-dependent protein kinase activity; IDA:SGD.
 GO:0007005; P:mitochondrion organization; IMP:SGD.
 GO:0007265; P:Ras protein signal transduction; IGI:SGD. 

Interpro

 IPR000961; AGC-kinase_C.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 

Pfam

 PF00069; Pkinase 

SMART

 SM00133; S_TK_X
 SM00220; S_TKc 

PROSITE

 PS51285; AGC_KINASE_CTER
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 

PRINTS