UniProt Accession

 HIS2_ECOLI; P06989; P78079; Q47596 

Genbank Protein ID

 X13462; X03974; U02072; D43637; U00096; AP009048 

Genbank Nucleotide ID

 CAA31818.1; CAA27613.1; AAA19744.1; BAA07753.1; AAC75087.1; BAA15858.1 

Protein Name

 Histidine biosynthesis bifunctional protein HisIE 

Protein Synonyms/Alias

 Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH 

Gene Name

 hisI 

Gene Synonyms/Alias

 hisIE; b2026; JW2008 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
50	DKTLESGKVTFFSRT	acetylation	[1]
137	PETSYTAKLYASGTK	acetylation	[1]
149	GTKRIAQKVGEEGVE	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

  

Sequence Annotation

 REGION 1 114 Phosphoribosyl-AMP cyclohydrolase.
 REGION 115 203 Phosphoribosyl-ATP pyrophosphohydrolase.  

Keyword

 Amino-acid biosynthesis; ATP-binding; Complete proteome; Cytoplasm; Histidine biosynthesis; Hydrolase; Multifunctional enzyme; Nucleotide-binding; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 203 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004635; F:phosphoribosyl-AMP cyclohydrolase activity; ISS:EcoCyc.
 GO:0004636; F:phosphoribosyl-ATP diphosphatase activity; IGI:EcoCyc.
 GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-UniPathway. 

Interpro

 IPR023019; His_synth_HisIE.
 IPR008179; PRib-ATP_PPHydrolase.
 IPR021130; PRib-ATP_PPHydrolase-like.
 IPR002496; PRib_AMP_CycHydrolase_dom. 

Pfam

 PF01502; PRA-CH
 PF01503; PRA-PH 

SMART

  

PROSITE

  

PRINTS