UniProt Accession

 J3QNG0_MOUSE; J3QNG0 

Genbank Protein ID

 AC164702; CH466553 

Genbank Nucleotide ID

 EDL32117.1 

Protein Name

 MCG15755 

Protein Synonyms/Alias

 Uncharacterized protein 

Gene Name

 Gm5424 

Gene Synonyms/Alias

 mCG_15755 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
41	YLANIGQKEDFEEAR	acetylation	[1]
41	YLANIGQKEDFEEAR	ubiquitination	[2]
53	EARKKALKLGAKKVF	acetylation	[3]
58	ALKLGAKKVFIEDVS	acetylation	[4]
58	ALKLGAKKVFIEDVS	ubiquitination	[2]
112	IAQREGAKYVSHGAT	acetylation	[1, 3, 4, 5]
112	IAQREGAKYVSHGAT	ubiquitination	[2]
121	VSHGATGKGNDQVRF	acetylation	[1, 3]
121	VSHGATGKGNDQVRF	ubiquitination	[2]
140	YSLAPQIKVIAPWRM	ubiquitination	[2]
155	PEFYNRFKGRNDLME	ubiquitination	[2]
165	NDLMEYAKQHGIPIP	acetylation	[1, 5, 6]
199	AGILENPKNQAPPGL	ubiquitination	[2]
228	DVLEIEFKKGVPVKV	acetylation	[1, 5]
234	FKKGVPVKVTNIKDG	ubiquitination	[2]
239	PVKVTNIKDGTTRTT	acetylation	[1]
239	PVKVTNIKDGTTRTT	ubiquitination	[2]
260	YLNEVAGKHGVGRID	acetylation	[3]
260	YLNEVAGKHGVGRID	ubiquitination	[2]
277	ENRFIGMKSRGIYET	ubiquitination	[2]
310	DREVRKIKQGLGLKF	ubiquitination	[2]
340	FVRHCIQKSQERVEG	acetylation	[1, 3, 4]
340	FVRHCIQKSQERVEG	phosphoglycerylation	[7]
340	FVRHCIQKSQERVEG	ubiquitination	[2]
355	KVQVSVFKGQVYILG	acetylation	[3]
408	EYHRLQSKVTAK***	ubiquitination	[2]

Reference

 [1] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [4] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [5] Circadian acetylome reveals regulation of mitochondrial metabolic pathways.
 Masri S, Patel VR, Eckel-Mahan KL, Peleg S, Forne I, Ladurner AG, Baldi P, Imhof A, Sassone-Corsi P.
 Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3339-44. [PMID: 23341599]
 [6] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [7] Functional lysine modification by an intrinsically reactive primary glycolytic metabolite.
 Moellering RE, Cravatt BF.
 Science. 2013 Aug 2;341(6145):549-53. [PMID: 23908237] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 412 AA 

Protein Sequence

Gene Ontology

 GO:0004055; F:argininosuccinate synthase activity; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0006526; P:arginine biosynthetic process; IEA:InterPro. 

Interpro

 IPR001518; Arginosuc_synth.
 IPR018223; Arginosuc_synth_CS.
 IPR023434; Arginosuc_synth_type_1_subfam.
 IPR024074; AS_cat/multimer_dom_body.
 IPR014729; Rossmann-like_a/b/a_fold. 

Pfam

 PF00764; Arginosuc_synth 

SMART

  

PROSITE

 PS00564; ARGININOSUCCIN_SYN_1
 PS00565; ARGININOSUCCIN_SYN_2 

PRINTS