CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019214
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Dysbindin 
Protein Synonyms/Alias
 Biogenesis of lysosome-related organelles complex 1 subunit 8; BLOC-1 subunit 8; Dysbindin-1; Dystrobrevin-binding protein 1; Hermansky-Pudlak syndrome 7 protein; HPS7 protein 
Gene Name
 DTNBP1 
Gene Synonyms/Alias
 BLOC1S8; My031 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
21QDFTSGLKTLSDKSRubiquitination[1]
31SDKSREAKVKSKPRTacetylation[2]
33KSREAKVKSKPRTVPacetylation[2]
35REAKVKSKPRTVPFLacetylation[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 
Functional Description
 Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. Plays a role in the regulation of cell surface exposure of DRD2. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation. Appears to promote neuronal transmission and viability through regulating the expression of SNAP25 and SYN1, modulating PI3-kinase-Akt signaling and influencing glutamatergic release. Regulates the expression of SYN1 through binding to its promoter. Modulates prefrontal cortical activity via the dopamine/D2 pathway. 
Sequence Annotation
 REGION 173 331 Dysbindin.
 REGION 243 256 Nuclear export signal.
 MOD_RES 31 31 N6-acetyllysine.
 MOD_RES 33 33 N6-acetyllysine.
 MOD_RES 35 35 N6-acetyllysine.
 MOD_RES 316 316 Phosphoserine.
 MOD_RES 321 321 Phosphoserine.  
Keyword
 Acetylation; Albinism; Alternative initiation; Alternative splicing; Cell junction; Cell membrane; Coiled coil; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Endoplasmic reticulum; Endosome; Hermansky-Pudlak syndrome; Membrane; Nucleus; Phosphoprotein; Polymorphism; Postsynaptic cell membrane; Reference proteome; Schizophrenia; Sensory transduction; Synapse; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 351 AA 
Protein Sequence
MLETLRERLL SVQQDFTSGL KTLSDKSREA KVKSKPRTVP FLPKYSAGLE LLSRYEDTWA 60
ALHRRAKDCA SAGELVDSEV VMLSAHWEKK KTSLVELQEQ LQQLPALIAD LESMTANLTH 120
LEASFEEVEN NLLHLEDLCG QCELERCKHM QSQQLENYKK NKRKELETFK AELDAEHAQK 180
VLEMEHTQQM KLKERQKFFE EAFQQDMEQY LSTGYLQIAE RREPIGSMSS MEVNVDMLEQ 240
MDLMDISDQE ALDVFLNSGG EENTVLSPAL GPESSTCQNE ITLQVPNPSE LRAKPPSSSS 300
TCTDSATRDI SEGGESPVVQ SDEEEVQVDT ALATSHTDRE ATPDGGEDSD S 351 
Gene Ontology
 GO:0033267; C:axon part; ISS:UniProtKB.
 GO:0031083; C:BLOC-1 complex; IDA:UniProtKB.
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
 GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
 GO:0030426; C:growth cone; ISS:UniProtKB.
 GO:0033162; C:melanosome membrane; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0014069; C:postsynaptic density; IDA:UniProtKB.
 GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
 GO:0042383; C:sarcolemma; ISS:UniProtKB.
 GO:0016528; C:sarcoplasm; IEA:Compara.
 GO:0030672; C:synaptic vesicle membrane; IDA:UniProtKB.
 GO:0031532; P:actin cytoskeleton reorganization; ISS:UniProtKB.
 GO:0008089; P:anterograde axon cargo transport; ISS:UniProtKB.
 GO:0048490; P:anterograde synaptic vesicle transport; ISS:UniProtKB.
 GO:0007596; P:blood coagulation; IEA:Compara.
 GO:0016044; P:cellular membrane organization; TAS:Reactome.
 GO:0032438; P:melanosome organization; NAS:UniProtKB.
 GO:0048812; P:neuron projection morphogenesis; ISS:UniProtKB.
 GO:0060155; P:platelet dense granule organization; IEA:Compara.
 GO:0010628; P:positive regulation of gene expression; ISS:UniProtKB.
 GO:0001956; P:positive regulation of neurotransmitter secretion; ISS:UniProtKB.
 GO:0006892; P:post-Golgi vesicle-mediated transport; TAS:Reactome.
 GO:0060159; P:regulation of dopamine receptor signaling pathway; ISS:UniProtKB.
 GO:0014059; P:regulation of dopamine secretion; ISS:UniProtKB. 
Interpro
 IPR007531; Dysbindin. 
Pfam
 PF04440; Dysbindin 
SMART
  
PROSITE
  
PRINTS