CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012749
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 UTP--glucose-1-phosphate uridylyltransferase 
Protein Synonyms/Alias
 UDP-glucose pyrophosphorylase; UDPGP; UGPase 
Gene Name
 UGP2 
Gene Synonyms/Alias
 UGP1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
91DSIQPYEKIKARGLPubiquitination[1]
291NKTRADVKGGTLTQYubiquitination[2]
319KAHVDEFKSVSKFKIacetylation[3]
438KLGSSFTKVQDYLRRacetylation[4]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [4] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 
Functional Description
 Plays a central role as a glucosyl donor in cellular metabolic pathways. 
Sequence Annotation
 REGION 457 508 Oligomerization.
 REGION 502 503 Critical for end-to-end subunit
 ACT_SITE 396 396 By similarity.
 METAL 127 127 Magnesium (By similarity).
 METAL 253 253 Magnesium (By similarity).
 MOD_RES 13 13 Phosphoserine.
 MOD_RES 438 438 N6-acetyllysine.  
Keyword
 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Magnesium; Metal-binding; Nucleotidyltransferase; Phosphoprotein; Polymorphism; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 508 AA 
Protein Sequence
MSRFVQDLSK AMSQDGASQF QEVIRQELEL SVKKELEKIL TTASSHEFEH TKKDLDGFRK 60
LFHRFLQEKG PSVDWGKIQR PPEDSIQPYE KIKARGLPDN ISSVLNKLVV VKLNGGLGTS 120
MGCKGPKSLI GVRNENTFLD LTVQQIEHLN KTYNTDVPLV LMNSFNTDED TKKILQKYNH 180
CRVKIYTFNQ SRYPRINKES LLPVAKDVSY SGENTEAWYP PGHGDIYASF YNSGLLDTFI 240
GEGKEYIFVS NIDNLGATVD LYILNHLMNP PNGKRCEFVM EVTNKTRADV KGGTLTQYEG 300
KLRLVEIAQV PKAHVDEFKS VSKFKIFNTN NLWISLAAVK RLQEQNAIDM EIIVNAKTLD 360
GGLNVIQLET AVGAAIKSFE NSLGINVPRS RFLPVKTTSD LLLVMSNLYS LNAGSLTMSE 420
KREFPTVPLV KLGSSFTKVQ DYLRRFESIP DMLELDHLTV SGDVTFGKNV SLKGTVIIIA 480
NHGDRIDIPP GAVLENKIVS GNLRILDH 508 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0003983; F:UTP:glucose-1-phosphate uridylyltransferase activity; TAS:UniProtKB.
 GO:0006006; P:glucose metabolic process; TAS:Reactome.
 GO:0005978; P:glycogen biosynthetic process; TAS:Reactome.
 GO:0016310; P:phosphorylation; NAS:UniProtKB.
 GO:0006011; P:UDP-glucose metabolic process; TAS:ProtInc.
 GO:0006065; P:UDP-glucuronate biosynthetic process; TAS:Reactome.
 GO:0006805; P:xenobiotic metabolic process; TAS:Reactome. 
Interpro
 IPR002618; UDPGP_trans.
 IPR016267; UDPGP_trans_subgr. 
Pfam
 PF01704; UDPGP 
SMART
  
PROSITE
  
PRINTS