UniProt Accession

 ANXA3_MOUSE; O35639; Q3UBI0 

Genbank Protein ID

 AJ001633; AK150922; AK150951; AK151771; AK152863; AK168396; AK168507; BC090634 

Genbank Nucleotide ID

 CAA04887.1; BAE29960.1; BAE29984.1; BAE30677.1; BAE31554.1; BAE40320.1; BAE40390.1; AAH90634.1 

Protein Name

 Annexin A3 

Protein Synonyms/Alias

 35-alpha calcimedin; Annexin III; Annexin-3; Lipocortin III; Placental anticoagulant protein III; PAP-III 

Gene Name

 Anxa3 

Gene Synonyms/Alias

 Anx3 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
69	AAYEQELKDDLKGDL	acetylation	[1]
69	AAYEQELKDDLKGDL	ubiquitination	[2]
104	KQLKKSMKGTGTDED	ubiquitination	[2]
126	TRSSRQMKEISQAYY	acetylation	[3]
137	QAYYTVYKKSLGDDI	acetylation	[1, 3]
154	ETSGDFRKALLTLAD	acetylation	[3]
177	VDEHLAKKDAQILYN	acetylation	[3, 4]
196	KWGTDEDKFTEVLCL	acetylation	[3]
210	LRSFPQLKLTFDEYR	ubiquitination	[2]
263	ERLHQALKGAGTDEF	acetylation	[1, 3]
263	ERLHQALKGAGTDEF	ubiquitination	[2]
293	DIRHEFKKHYGYSLY	acetylation	[3]

Reference

 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Inhibitor of phospholipase A2, also possesses anti- coagulant properties. 

Sequence Annotation

 REPEAT 27 87 Annexin 1.
 REPEAT 99 159 Annexin 2.
 REPEAT 183 243 Annexin 3.
 REPEAT 258 318 Annexin 4.
 MOD_RES 2 2 N-acetylalanine (By similarity).  

Keyword

 Acetylation; Annexin; Calcium; Calcium/phospholipid-binding; Complete proteome; Phospholipase A2 inhibitor; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 323 AA 

Protein Sequence

Gene Ontology

 GO:0030670; C:phagocytic vesicle membrane; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0042581; C:specific granule; IEA:Compara.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0005544; F:calcium-dependent phospholipid binding; IEA:UniProtKB-KW.
 GO:0019834; F:phospholipase A2 inhibitor activity; IEA:UniProtKB-KW.
 GO:0042742; P:defense response to bacterium; IEA:Compara.
 GO:0043312; P:neutrophil degranulation; IEA:Compara.
 GO:0006909; P:phagocytosis; IEA:Compara.
 GO:0045766; P:positive regulation of angiogenesis; IEA:Compara.
 GO:0010595; P:positive regulation of endothelial cell migration; IEA:Compara.
 GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IEA:Compara. 

Interpro

 IPR001464; Annexin.
 IPR018502; Annexin_repeat.
 IPR018252; Annexin_repeat_CS.
 IPR002390; AnnexinIII. 

Pfam

 PF00191; Annexin 

SMART

 SM00335; ANX 

PROSITE

 PS00223; ANNEXIN 

PRINTS

 PR00196; ANNEXIN.
 PR00199; ANNEXINIII.