UniProt Accession

 YBOX3_MOUSE; Q9JKB3; Q80WG4; Q9EQF7; Q9EQF8 

Genbank Protein ID

 AF246224; AF248546; AF248547; BC048242; BC062377 

Genbank Nucleotide ID

 AAF61741.1; AAG14418.1; AAG14419.1; AAH48242.1; AAH62377.1 

Protein Name

 Y-box-binding protein 3 

Protein Synonyms/Alias

 Cold shock domain-containing protein A; DNA-binding protein A; Y-box protein 3 

Gene Name

 Ybx3 

Gene Synonyms/Alias

 Csda; Msy4 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
191	AGEIGEMKDGVPEGT	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Binds to the GM-CSF promoter. Seems to act as a repressor (By similarity). Binds also to full length mRNA and to short RNA sequences containing the consensus site 5'-UCCAUCA-3'. May have a role in translation repression. 

Sequence Annotation

 DOMAIN 82 152 CSD.
 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 126 126 Phosphoserine (By similarity).
 MOD_RES 193 193 Phosphoserine (By similarity).
 MOD_RES 195 195 Phosphoserine (By similarity).
 MOD_RES 196 196 Phosphoserine (By similarity).
 MOD_RES 277 277 Phosphotyrosine.
 MOD_RES 313 313 Phosphoserine (By similarity).
 MOD_RES 328 328 Phosphoserine.  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Cytoplasm; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Repressor; RNA-binding; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 361 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0005921; C:gap junction; ISO:MGI.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0003677; F:DNA binding; IDA:MGI.
 GO:0003730; F:mRNA 3'-UTR binding; IDA:MGI.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0003697; F:single-stranded DNA binding; IDA:MGI.
 GO:0071474; P:cellular hyperosmotic response; IEA:Compara.
 GO:0071356; P:cellular response to tumor necrosis factor; IEA:Compara.
 GO:0009566; P:fertilization; IMP:MGI.
 GO:0001701; P:in utero embryonic development; IGI:MGI.
 GO:0008584; P:male gonad development; IMP:MGI.
 GO:0043066; P:negative regulation of apoptotic process; IMP:MGI.
 GO:0060547; P:negative regulation of necrotic cell death; IEA:Compara.
 GO:0048642; P:negative regulation of skeletal muscle tissue development; IDA:MGI.
 GO:0046622; P:positive regulation of organ growth; IMP:MGI.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0007283; P:spermatogenesis; IMP:MGI.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR019844; Cold-shock_CS.
 IPR011129; Cold_shock_prot.
 IPR002059; CSP_DNA-bd.
 IPR012340; NA-bd_OB-fold. 

Pfam

 PF00313; CSD 

SMART

 SM00357; CSP 

PROSITE

 PS00352; COLD_SHOCK 

PRINTS

 PR00050; COLDSHOCK.