UniProt Accession

 PTN9_HUMAN; P43378; Q53XR9 

Genbank Protein ID

 M83738; BT007405; BC010863 

Genbank Nucleotide ID

 AAA60226.1; AAP36073.1; AAH10863.1 

Protein Name

 Tyrosine-protein phosphatase non-receptor type 9 

Protein Synonyms/Alias

 Protein-tyrosine phosphatase MEG2; PTPase MEG2 

Gene Name

 PTPN9 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
185	AFPARLKKVLIVGAP	ubiquitination	[1]
218	RERIQILKTSEVTQH	ubiquitination	[2, 3]
300	DYVNARQKQGIYEEY	ubiquitination	[2]
444	ENMNHYKKTTLEIHN	ubiquitination	[2]
503	SNMGARSKGQCPEPP	ubiquitination	[2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 Protein-tyrosine phosphatase that could participate in the transfer of hydrophobic ligands or in functions of the Golgi apparatus. 

Sequence Annotation

 DOMAIN 84 243 CRAL-TRIO.
 DOMAIN 303 574 Tyrosine-protein phosphatase.
 REGION 515 521 Substrate binding (By similarity).
 ACT_SITE 515 515 Phosphocysteine intermediate (By
 BINDING 470 470 Substrate (By similarity).
 BINDING 559 559 Substrate (By similarity).
 MOD_RES 1 1 N-acetylmethionine.  

Keyword

 3D-structure; Acetylation; Complete proteome; Cytoplasm; Hydrolase; Protein phosphatase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 593 AA 

Protein Sequence

Gene Ontology

 GO:0044444; C:cytoplasmic part; IDA:UniProtKB.
 GO:0004726; F:non-membrane spanning protein tyrosine phosphatase activity; TAS:ProtInc. 

Interpro

 IPR001251; CRAL-TRIO_dom.
 IPR011074; CRAL/TRIO_N_dom.
 IPR000387; Tyr/Dual-sp_Pase.
 IPR016130; Tyr_Pase_AS.
 IPR000242; Tyr_Pase_rcpt/non-rcpt. 

Pfam

 PF00650; CRAL_TRIO
 PF03765; CRAL_TRIO_N
 PF00102; Y_phosphatase 

SMART

 SM01100; CRAL_TRIO_N
 SM00194; PTPc
 SM00516; SEC14 

PROSITE

 PS50191; CRAL_TRIO
 PS00383; TYR_PHOSPHATASE_1
 PS50056; TYR_PHOSPHATASE_2
 PS50055; TYR_PHOSPHATASE_PTP 

PRINTS

 PR00700; PRTYPHPHTASE.