UniProt Accession

 PHNP_ECOLI; P16692; Q2M6L1 

Genbank Protein ID

 J05260; D90227; U14003; U00096; AP009048 

Genbank Nucleotide ID

 AAA24356.1; BAA14276.1; AAA96991.1; AAC77053.1; BAE78095.1 

Protein Name

 Phosphoribosyl 1,2-cyclic phosphodiesterase 

Protein Synonyms/Alias

 Phosphoribosyl cyclic phosphodiesterase 

Gene Name

 phnP 

Gene Synonyms/Alias

 b4092; JW4053 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
171	DTAGLPEKTLKFLRN	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Catalyzes the hydrolysis of the cyclic ribose-phosphate to form alpha-D-ribose 1,5-bisphosphate. 

Sequence Annotation

 METAL 21 21 Zinc.
 METAL 23 23 Zinc.
 METAL 26 26 Zinc.
 METAL 76 76 Manganese 1; via tele nitrogen.
 METAL 78 78 Manganese 1; via pros nitrogen.
 METAL 80 80 Manganese 2.
 METAL 81 81 Manganese 2; via tele nitrogen.
 METAL 143 143 Manganese 1; via tele nitrogen.
 METAL 164 164 Manganese 1.
 METAL 164 164 Manganese 2.
 METAL 222 222 Manganese 2; via tele nitrogen.
 METAL 225 225 Zinc; via pros nitrogen.  

Keyword

 3D-structure; Complete proteome; Hydrolase; Manganese; Metal-binding; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 252 AA 

Protein Sequence

Gene Ontology

 GO:0030145; F:manganese ion binding; IDA:EcoCyc.
 GO:0008081; F:phosphoric diester hydrolase activity; IDA:EcoCyc.
 GO:0019700; P:organic phosphonate catabolic process; IMP:EcoCyc. 

Interpro

 IPR001279; Beta-lactamas-like.
 IPR017693; Phosphonate_metab_PhnP. 

Pfam

  

SMART

 SM00849; Lactamase_B 

PROSITE

  

PRINTS