| Tag | Content |
|---|
| CPLM ID | CPLM-001425 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | ATP-sensitive inward rectifier potassium channel 15 |
Protein Synonyms/Alias | Inward rectifier K(+) channel Kir4.2; Potassium channel, inwardly rectifying subfamily J member 15 |
Gene Name | Kcnj15 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 223 | LLQTHVTKEGERILL | ubiquitination | [1] | | 335 | SQFEQIRKSPDCTFY | ubiquitination | [1] | | 348 | FYCADSEKQKLEEQY | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. |
Sequence Annotation | MOTIF 127 132 Selectivity filter (By similarity). |
Keyword | Complete proteome; Ion channel; Ion transport; Membrane; Potassium; Potassium transport; Reference proteome; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 375 AA |
Protein Sequence | MDAIHLGMSS APLVKHTNGV GLKAHRPRVM SKSGHSNVRI DKVDGIYLLY LQDLWTTVID 60
MKWRYKLTLF AATFVMTWFL FGVVYYAIAF IHGDLQLGES NSNHTPCIMK VDSLTGAFLF 120
SLESQTTIGY GVRSITEECP HAIFLLVAQL VITTLIEIFI TGTFLAKIAR PKKRAETIKF 180
SHCAVISKQN GKLCLVIQVA NMRKSLLIQC QLSGKLLQTH VTKEGERILL NQATVKFHVD 240
SSSESPFLIL PMTFYHVLDE TSPLRDLTPQ NLKEKEFELV VLLNATVEST SAVCQSRTSY 300
IPEEIYWGFE FVPVVSLSKN GKYVADFSQF EQIRKSPDCT FYCADSEKQK LEEQYRQEDQ 360
RERELRSLLL QQSNV 375 |
Gene Ontology | GO:0016021; C:integral to membrane; IC:MGI. GO:0005242; F:inward rectifier potassium channel activity; IEA:InterPro. GO:0005267; F:potassium channel activity; IDA:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |