UniProt Accession

 KRA51_HUMAN; Q6L8H4 

Genbank Protein ID

 AB126070 

Genbank Nucleotide ID

 BAD20197.1 

Protein Name

 Keratin-associated protein 5-1 

Protein Synonyms/Alias

 Keratin, cuticle, ultrahigh sulphur 1-like; Keratin-associated protein 5.1; Ultrahigh sulfur keratin-associated protein 5.1 

Gene Name

 KRTAP5-1 

Gene Synonyms/Alias

 KAP5.1; KRN1L; KRTAP5.1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
154	CSCSSCGKGGCGSCG	ubiquitination	[1]
164	CGSCGCSKGACGSCG	ubiquitination	[1]
174	CGSCGGSKGGCGSCG	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins. 

Sequence Annotation

 REPEAT 42 45 1.
 REPEAT 48 51 2.
 REPEAT 130 133 3.
 REPEAT 136 139 4.
 REPEAT 142 145 5.
 REPEAT 239 242 6.
 REPEAT 258 261 7.
 REPEAT 268 271 8.
 REGION 42 271 8 X 4 AA repeats of C-C-X-P.  

Keyword

 Complete proteome; Keratin; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 278 AA 

Protein Sequence

Gene Ontology

 GO:0045095; C:keratin filament; IEA:InterPro. 

Interpro

 IPR002494; Keratin-assoc. 

Pfam

  

SMART

  

PROSITE

  

PRINTS