CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039596
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Histone deacetylase 4 
Protein Synonyms/Alias
  
Gene Name
 HDAC4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
321RQKLDSKKLLGSLASubiquitination[1]
610KVMEIHSKYWRCLQRubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 668 AA 
Protein Sequence
MVLLEQPPAQ APLVTGLGAL PLHAQSLVGA DRVSPSIHKL RQHRPLGRTQ SAPLPQNAQA 60
LQHLVIQQQH QQFLEKHKQQ FQQQQLQMNK IIPKPSEPAR QPESHPEETE EELREHQALL 120
DEPYLDRLPG QKEAHAQAGV QVKQEPIESD EEEAEPPREV EPGQRQPSEQ ELLFRQQALL 180
LEQQRIHQLR NYQASMEAAG IPVSFGGHRP LSRAQSSPAS ATFPVSVQEP PTKPRFTTGL 240
VYDTLMLKHQ CTCGSSSSHP EHAGRIQSIW SRLQETGLRG KCECIRGRKA TLEELQTVHS 300
EAHTLLYGTN PLNRQKLDSK KLLGSLASVF VRLPCGGVGV DSDTIWNEVH SAGAARLAVG 360
CVVELVFKVA TGELKNGFAV VRPPGHHAEE STPMGFCYFN SVAVAAKLLQ QRLSVSKILI 420
VDWDVHHGNG TQQAFYSDPS VLYMSLHRYD DGNFFPGSGA PDEVGTGPGV GFNVNMAFTG 480
GLDPPMGDAE YLAAFRTVVM PIASEFAPDV VLVSSGFDAV EGHPTPLGGY NLSARCFGYL 540
TKQLMGLAGG RIVLALEGGH DLTAICDASE ACVSALLGNE LDPLPEKVLQ QRPNANAVRS 600
MEKVMEIHSK YWRCLQRTTS TAGRSLIEAQ TCENEEAETV TAMASLSVGV KPAEKRPDEE 660
PMEEEPPL 668 
Gene Ontology
 GO:0031672; C:A band; IEA:Compara.
 GO:0042641; C:actomyosin; IEA:Compara.
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0031594; C:neuromuscular junction; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0030018; C:Z disc; IEA:Compara.
 GO:0003677; F:DNA binding; IEA:Compara.
 GO:0033558; F:protein deacetylase activity; IEA:Compara.
 GO:0003714; F:transcription corepressor activity; IEA:Compara.
 GO:0008285; P:negative regulation of cell proliferation; IEA:Compara.
 GO:0045820; P:negative regulation of glycolysis; IEA:Compara.
 GO:0045668; P:negative regulation of osteoblast differentiation; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0002076; P:osteoblast development; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0006476; P:protein deacetylation; IEA:GOC.
 GO:0010882; P:regulation of cardiac muscle contraction by calcium ion signaling; IEA:Compara.
 GO:0048742; P:regulation of skeletal muscle fiber development; IEA:Compara.
 GO:0014894; P:response to denervation involved in regulation of muscle adaptation; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0001501; P:skeletal system development; IEA:Compara. 
Interpro
 IPR019154; Arb2_domain.
 IPR000286; His_deacetylse.
 IPR023801; His_deacetylse_dom. 
Pfam
 PF09757; Arb2
 PF00850; Hist_deacetyl 
SMART
  
PROSITE
  
PRINTS
 PR01270; HDASUPER.