| Tag | Content |
|---|
| CPLM ID | CPLM-019682 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Very-long-chain enoyl-CoA reductase |
Protein Synonyms/Alias | Enoyl reductase TSC13; Temperature-sensitive CSG2 suppressor protein 13; Trans-2-enoyl-CoA reductase |
Gene Name | TSC13 |
Gene Synonyms/Alias | YDL015C; D2865 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 21 | DTEIDLSKKPTLDDV | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long chain fatty acids (VLCFA) from palmitate. Catalyzes the last step in each elongation cycle that lengthens palmitate by two carbon units. VLCFAs serve as precursors for ceramide and sphingolipids. Required for normal biogenesis of piecemeal microautophagy of the nucleus (PMN) bleps and vesicles during nutrient stress. |
Sequence Annotation | |
Keyword | Complete proteome; Endoplasmic reticulum; Lipid biosynthesis; Lipid metabolism; Membrane; NADP; Oxidoreductase; Reference proteome; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 310 AA |
Protein Sequence | MPITIKSRSK GLRDTEIDLS KKPTLDDVLK KISANNHNIS KYRIRLTYKK ESKQVPVISE 60
SFFQEEADDS MEFFIKDLGP QISWRLVFFC EYLGPVLVHS LFYYLSTIPT VVDRWHSASS 120
DYNPFLNRVA YFLILGHYGK RLFETLFVHQ FSLATMPIFN LFKNCFHYWV LSGLISFGYF 180
GYGFPFGNAK LFKYYSYLKL DDLSTLIGLF VLSELWNFYC HIKLRLWGDY QKKHGNAKIR 240
VPLNQGIFNL FVAPNYTFEV WSWIWFTFVF KFNLFAVLFL TVSTAQMYAW AQKKNKKYHT 300
RRAFLIPFVF 310 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; IDA:SGD. GO:0016021; C:integral to membrane; ISM:SGD. GO:0005739; C:mitochondrion; IDA:SGD. GO:0016491; F:oxidoreductase activity; IMP:SGD. GO:0016627; F:oxidoreductase activity, acting on the CH-CH group of donors; IEA:InterPro. GO:0000038; P:very long-chain fatty acid metabolic process; IMP:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |