CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016095
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Acyl-CoA dehydrogenase family member 11 
Protein Synonyms/Alias
 ACAD-11 
Gene Name
 Acad11 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
17VEVLPQHKFDLRSLEubiquitination[1]
60NPTFFLQKGSQAYVLubiquitination[1]
81SLLPKAHKIDREFKIacetylation[2]
87HKIDREFKIQKALFSacetylation[2]
90DREFKIQKALFSIGFacetylation[2]
166IRSLKLDKYGTGVGYacetylation[2, 3]
166IRSLKLDKYGTGVGYubiquitination[1]
175GTGVGYCKRQVSTWTacetylation[2]
175GTGVGYCKRQVSTWTubiquitination[1]
222CLVHGDFKLDNIVFHubiquitination[1]
355ETGLQLSKRTLRTTPubiquitination[1]
368TPPQADAKSQLFAQSacetylation[2]
368TPPQADAKSQLFAQSubiquitination[1]
390TRVKQFMKQHVFPAEacetylation[2]
413QSGNSAEKWGHPLVIacetylation[2]
413QSGNSAEKWGHPLVIubiquitination[1]
488YGSEQQKKQWLEPLLubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [3] Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.
 Kim SC, Sprung R, Chen Y, Xu Y, Ball H, Pei J, Cheng T, Kho Y, Xiao H, Xiao L, Grishin NV, White M, Yang XJ, Zhao Y.
 Mol Cell. 2006 Aug;23(4):607-18. [PMID: 16916647] 
Functional Description
 Acyl-CoA dehydrogenase, that exhibits maximal activity towards saturated C22-CoA (By similarity). 
Sequence Annotation
 NP_BIND 503 513 FAD (By similarity).
 NP_BIND 503 506 FAD (By similarity).
 NP_BIND 511 513 FAD (By similarity).
 NP_BIND 537 539 FAD (By similarity).
 NP_BIND 726 730 FAD; shared with dimeric partner (By
 NP_BIND 755 757 FAD (By similarity).
 REGION 628 631 Substrate binding (By similarity).
 BINDING 513 513 Substrate; via carbonyl oxygen (By
 BINDING 539 539 FAD (By similarity).
 BINDING 656 656 FAD (By similarity).
 BINDING 656 656 FAD; shared with dimeric partner (By
 BINDING 726 726 FAD (By similarity).
 BINDING 754 754 Substrate; via amide nitrogen (By
 BINDING 757 757 FAD (By similarity).
 MOD_RES 166 166 N6-acetyllysine.
 MOD_RES 323 323 Phosphotyrosine.  
Keyword
 Acetylation; Complete proteome; FAD; Flavoprotein; Mitochondrion; Oxidoreductase; Peroxisome; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 779 AA 
Protein Sequence
METDVTSDTV EVLPQHKFDL RSLEAYLNQH LPGFGSDSRA VLTVTQYRSG QSNPTFFLQK 60
GSQAYVLRKK PPGSLLPKAH KIDREFKIQK ALFSIGFPVA KPLLYCRDAS VIGTEFYVME 120
HVQGRIFRDF SIPGVSSAER AAIYVSVAET LAWLHSLDIR SLKLDKYGTG VGYCKRQVST 180
WTKQYQASAH QSIPAMDQLS TWLMKNLPDS DSEECLVHGD FKLDNIVFHP KECRVIAVLD 240
WELSTFGHPL TDLAHLSLFY YWPRTLPMIN RGSHIPENTG IPLMEELISI YCHRRGIDPN 300
LPNWNFFMAL SFFKLAGISQ GVYRRYLMGN NSSEDSFLTA NTVQPLAETG LQLSKRTLRT 360
TPPQADAKSQ LFAQSRRGQE VLTRVKQFMK QHVFPAEKEV AEYYAQSGNS AEKWGHPLVI 420
EKLKEMAKAE GLWNLFLPAV SGLSQVDYAL IAEETGKCFF APDVFNCQAP DTGNMEVLHL 480
YGSEQQKKQW LEPLLRGDIT SVFCMTEPNV SSSDATNIEC TIQRDGGGYI VNGKKWWSSG 540
AGNPKCKIAI VLGRTESPSA SRHRQHSMIL VPMDTPGVEL IRPLSVFGYM DNMHGGHWEV 600
HFNHVRVPAS NLILGEGRGF EISQGRLGPG RIHHCMRTVG LAERILQIMC DRAVQREAFK 660
KKLYEHEVVA HWIAKSRIAI EEIRLLTLKA AHSIDTLGSA SARKEIAMIK VAAPKAVCKI 720
ADWAIQVHGG AGVSQDYPLA NMYAIIRTLR LADGPDEVHL SAIAKMELQD QARRLTARM 779 
Gene Ontology
 GO:0031966; C:mitochondrial membrane; IEA:Compara.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0005777; C:peroxisome; ISS:HGNC.
 GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
 GO:0070991; F:medium-chain-acyl-CoA dehydrogenase activity; IEA:Compara.
 GO:0016772; F:transferase activity, transferring phosphorus-containing groups; IEA:InterPro.
 GO:0017099; F:very-long-chain-acyl-CoA dehydrogenase activity; IEA:Compara.
 GO:0033539; P:fatty acid beta-oxidation using acyl-CoA dehydrogenase; IEA:Compara. 
Interpro
 IPR006092; Acyl-CoA_DH_N.
 IPR006090; Acyl-CoA_Oxase/DH_1.
 IPR006091; Acyl-CoA_Oxase/DH_cen-dom.
 IPR009075; AcylCo_DH/oxidase_C.
 IPR013786; AcylCoA_DH/ox_N.
 IPR009100; AcylCoA_DH/oxidase.
 IPR002575; Aminoglycoside_PTrfase.
 IPR011009; Kinase-like_dom. 
Pfam
 PF00441; Acyl-CoA_dh_1
 PF02770; Acyl-CoA_dh_M
 PF02771; Acyl-CoA_dh_N
 PF01636; APH 
SMART
  
PROSITE
  
PRINTS