UniProt Accession

 Q4W5L4_HUMAN; Q4W5L4 

Genbank Protein ID

 AC093752 

Genbank Nucleotide ID

 AAY40985.1 

Protein Name

 Putative uncharacterized protein PDE5A 

Protein Synonyms/Alias

  

Gene Name

 PDE5A 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
170	EEYKTTLKIIKQAIL	ubiquitination	[1]

Reference

 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

  

Sequence Annotation

  

Keyword

 Hydrolase; Metal-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 331 AA 

Protein Sequence

Gene Ontology

 GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; IEA:Compara.
 GO:0030553; F:cGMP binding; IEA:Compara.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0046068; P:cGMP metabolic process; IEA:Compara.
 GO:0055118; P:negative regulation of cardiac muscle contraction; IEA:Compara.
 GO:0042130; P:negative regulation of T cell proliferation; IEA:Compara.
 GO:0010613; P:positive regulation of cardiac muscle hypertrophy; IEA:Compara.
 GO:0043406; P:positive regulation of MAP kinase activity; IEA:Compara.
 GO:0060282; P:positive regulation of oocyte development; IEA:Compara.
 GO:0055119; P:relaxation of cardiac muscle; IEA:Compara.
 GO:0007165; P:signal transduction; IEA:InterPro. 

Interpro

 IPR003607; HD/PDEase_dom.
 IPR023088; PDEase.
 IPR002073; PDEase_catalytic_dom.
 IPR023174; PDEase_CS. 

Pfam

 PF00233; PDEase_I 

SMART

 SM00471; HDc 

PROSITE

 PS00126; PDEASE_I 

PRINTS

 PR00387; PDIESTERASE1.