CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027792
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cytochrome b-c1 complex subunit 7 
Protein Synonyms/Alias
  
Gene Name
 Uqcrb 
Gene Synonyms/Alias
 mCG_67985 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
12SAVSASSKWLDGFRKacetylation[1, 2, 3, 4, 5]
12SAVSASSKWLDGFRKsuccinylation[4]
12SAVSASSKWLDGFRKubiquitination[6]
19KWLDGFRKWYYNAAGacetylation[1, 2, 3, 4]
19KWLDGFRKWYYNAAGsuccinylation[4]
29YNAAGFNKLGLMRDDacetylation[1]
45LHETEDVKEAIRRLPacetylation[3, 5]
78MRHQILPKDQWTKYEacetylation[1, 2, 3, 4, 5, 7]
78MRHQILPKDQWTKYEsuccinylation[4]
83LPKDQWTKYEEDKFYacetylation[1, 3, 5, 7]
88WTKYEEDKFYLEPYLacetylation[1, 2, 3, 4, 5, 7, 8]
88WTKYEEDKFYLEPYLsuccinylation[4]
96FYLEPYLKEVIRERKacetylation[1, 2, 3, 5]
110KEREEWAKK******acetylation[5]
Reference
 [1] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379]
 [2] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [3] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [5] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [6] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [7] Circadian acetylome reveals regulation of mitochondrial metabolic pathways.
 Masri S, Patel VR, Eckel-Mahan KL, Peleg S, Forne I, Ladurner AG, Baldi P, Imhof A, Sassone-Corsi P.
 Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3339-44. [PMID: 23341599]
 [8] Mitochondrial acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice.
 Fritz KS, Galligan JJ, Hirschey MD, Verdin E, Petersen DR.
 J Proteome Res. 2012 Mar 2;11(3):1633-43. [PMID: 22309199
Functional Description
 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain (By similarity). 
Sequence Annotation
  
Keyword
 Complete proteome; Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Respiratory chain; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 111 AA 
Protein Sequence
MAGRSAVSAS SKWLDGFRKW YYNAAGFNKL GLMRDDTLHE TEDVKEAIRR LPEDLYNDRM 60
FRIKRALDLT MRHQILPKDQ WTKYEEDKFY LEPYLKEVIR ERKEREEWAK K 111 
Gene Ontology
 GO:0005743; C:mitochondrial inner membrane; IDA:MGI.
 GO:0005750; C:mitochondrial respiratory chain complex III; IEA:InterPro.
 GO:0006122; P:mitochondrial electron transport, ubiquinol to cytochrome c; IEA:InterPro. 
Interpro
 IPR003197; QCR7. 
Pfam
 PF02271; UCR_14kD 
SMART
  
PROSITE
  
PRINTS