| Tag | Content |
|---|
| CPLM ID | CPLM-008334 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Probable E3 ubiquitin-protein ligase RNF144A |
Protein Synonyms/Alias | RING finger protein 144A; UbcM4-interacting protein 4; Ubiquitin-conjugating enzyme 7-interacting protein 4 |
Gene Name | RNF144A |
Gene Synonyms/Alias | KIAA0161; RNF144; UBCE7IP4 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 183 | EEDDAPIKRCPKCKV | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (By similarity). |
Sequence Annotation | ZN_FING 20 70 RING-type 1; atypical.
ZN_FING 91 156 IBR-type.
ZN_FING 185 214 RING-type 2; degenerate. |
Keyword | 3D-structure; Complete proteome; Ligase; Membrane; Metal-binding; Polymorphism; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Ubl conjugation pathway; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 292 AA |
Protein Sequence | MTTTRYRPTW DLALDPLVSC KLCLGEYPVE QMTTIAQCQC IFCTLCLKQY VELLIKEGLE 60
TAISCPDAAC PKQGHLQENE IECMVAAEIM QRYKKLQFER EVLFDPCRTW CPASTCQAVC 120
QLQDVGLQTP QPVQCKACRM EFCSTCKASW HPGQGCPETM PITFLPGETS AAFKMEEDDA 180
PIKRCPKCKV YIERDEGCAQ MMCKNCKHAF CWYCLESLDD DFLLIHYDKG PCRNKLGHSR 240
ASVIWHRTQV VGIFAGFGLL LLVASPFLLL ATPFVLCCKC KCSKGDDDPL PT 292 |
Gene Ontology | GO:0005794; C:Golgi apparatus; IDA:UniProtKB. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0016874; F:ligase activity; IEA:UniProtKB-KW. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |