| Tag | Content |
|---|
| CPLM ID | CPLM-017234 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 3 |
Protein Synonyms/Alias | 3-hydroxyacyl-CoA dehydratase 3; HACD3; Butyrate-induced protein 1; B-ind1; Protein tyrosine phosphatase-like protein PTPLAD1; Protein-tyrosine phosphatase-like A domain-containing protein 1 |
Gene Name | ptplad1 |
Gene Synonyms/Alias | hacd3 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 43 | TDNVLHFKAQGHGAK | ubiquitination | [1] | | 98 | ERLTKQEKRPLFLAP | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Responsible for the dehydration step in very long-chain fatty acid (VLCFA) synthesis. Involved in Rac1-signaling pathways leading to the modulation of gene expression. |
Sequence Annotation | DOMAIN 5 94 CS.
ACT_SITE 286 286 By similarity.
ACT_SITE 293 293 By similarity.
MOD_RES 114 114 Phosphoserine. |
Keyword | Coiled coil; Complete proteome; Endoplasmic reticulum; Fatty acid biosynthesis; Fatty acid metabolism; Lipid biosynthesis; Lipid metabolism; Lyase; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 362 AA |
Protein Sequence | METQVLTPHV YWAQRHRELY LRVELSDVQN PAISITDNVL HFKAQGHGAK GDNVYEFHLE 60
FLDLVKPEPA YRLTQRQVNI TVQKKGSHWW ERLTKQEKRP LFLAPDFDRW LDESDAEMEL 120
RAKEEERLNK LRLEREGSPE TLTNLKKGYL FMYNLVQLLG FSWIFVNLTV RFFILGKESF 180
YDTFHNVADM MYFCQMLALV ETLNAAIGVT STPVLPALIQ FLGRNFILFL VFGTMEEMQN 240
KAVVFFVFYS WSAIEIFRYP FYMLSCIDMD WKVLTWLRYT MWIPLYPLGC LSEAVAVIQS 300
IPVFNESGRF SFTLPYPVKM KVRFSFFLQV YLVMLFLGLY INFRHLYKQR RRRYGQKKKK 360
LH 362 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0016829; F:lyase activity; IEA:UniProtKB-KW. GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW. GO:0007249; P:I-kappaB kinase/NF-kappaB cascade; IDA:MGI. GO:0007254; P:JNK cascade; IDA:MGI. GO:0007266; P:Rho protein signal transduction; IDA:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |