UniProt Accession

 NRDR_ECOLI; P0A8D0; P25538; Q2MC13; Q3ZUB1 

Genbank Protein ID

 X64395; AM076828; U82664; U00096; AP009048 

Genbank Nucleotide ID

 CAA45734.1; CAJ28592.1; AAB40169.1; AAC73516.1; BAE76193.1 

Protein Name

 Transcriptional repressor NrdR 

Protein Synonyms/Alias

  

Gene Name

 nrdR 

Gene Synonyms/Alias

 ybaD; b0413; JW0403 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
65	REPFNEEKLRSGMLR	acetylation	[1]
92	EMAINHIKSQLRATG	acetylation	[1]
117	NLVMEQLKKLDKVAY	acetylation	[1]
121	EQLKKLDKVAYIRFA	acetylation	[1]
138	YRSFEDIKEFGEEIA	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Represses transcription of the class Ib RNR genes nrdHIEF but has much smaller effect on transcription of the class Ia RNR genes nrdAB and class III RNR genes nrdDG. By binding to nrdR boxes in the promoter regions to alter promoter activity, nrdR differentially regulates nrdAB, nrdHIEF and nrdD transcription in aerobic growth. 

Sequence Annotation

 DOMAIN 49 139 ATP-cone.
 ZN_FING 3 34 By similarity.  

Keyword

 ATP-binding; Complete proteome; DNA-binding; Metal-binding; Nucleotide-binding; Reference proteome; Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 149 AA 

Protein Sequence

Gene Ontology

 GO:0005524; F:ATP binding; IEA:HAMAP.
 GO:0003690; F:double-stranded DNA binding; IDA:EcoCyc.
 GO:0008270; F:zinc ion binding; IEA:HAMAP.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IMP:EcoCyc.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR005144; ATP-cone.
 IPR003796; RNR_NrdR-like. 

Pfam

 PF03477; ATP-cone 

SMART

  

PROSITE

 PS51161; ATP_CONE 

PRINTS