CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019519
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Diacylglycerol O-acyltransferase 2 
Protein Synonyms/Alias
 Acyl-CoA retinol O-fatty-acyltransferase; ARAT; Retinol O-fatty-acyltransferase; Diglyceride acyltransferase 2 
Gene Name
 DGAT2 
Gene Synonyms/Alias
 HMFN1045; UNQ738/PRO1433 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
146YFPIQLVKTHNLLTTubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides (By similarity). Functions also as an acyl-CoA retinol acyltransferase (ARAT). 
Sequence Annotation
  
Keyword
 Acyltransferase; Alternative splicing; Complete proteome; Endoplasmic reticulum; Glycerol metabolism; Lipid biosynthesis; Lipid droplet; Lipid metabolism; Membrane; Polymorphism; Reference proteome; Transferase; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 388 AA 
Protein Sequence
MKTLIAAYSG VLRGERQAEA DRSQRSHGGP ALSREGSGRW GTGSSILSAL QDLFSVTWLN 60
RSKVEKQLQV ISVLQWVLSF LVLGVACSAI LMYIFCTDCW LIAVLYFTWL VFDWNTPKKG 120
GRRSQWVRNW AVWRYFRDYF PIQLVKTHNL LTTRNYIFGY HPHGIMGLGA FCNFSTEATE 180
VSKKFPGIRP YLATLAGNFR MPVLREYLMS GGICPVSRDT IDYLLSKNGS GNAIIIVVGG 240
AAESLSSMPG KNAVTLRNRK GFVKLALRHG ADLVPIYSFG ENEVYKQVIF EEGSWGRWVQ 300
KKFQKYIGFA PCIFHGRGLF SSDTWGLVPY SKPITTVVGE PITIPKLEHP TQQDIDLYHT 360
MYMEALVKLF DKHKTKFGLP ETEVLEVN 388 
Gene Ontology
 GO:0030176; C:integral to endoplasmic reticulum membrane; ISS:BHF-UCL.
 GO:0005811; C:lipid particle; IEA:UniProtKB-SubCell.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; ISS:BHF-UCL.
 GO:0003846; F:2-acylglycerol O-acyltransferase activity; IEA:Compara.
 GO:0004144; F:diacylglycerol O-acyltransferase activity; IDA:UniProtKB.
 GO:0042803; F:protein homodimerization activity; ISS:BHF-UCL.
 GO:0050252; F:retinol O-fatty-acyltransferase activity; IEA:EC.
 GO:0036155; P:acylglycerol acyl-chain remodeling; TAS:Reactome.
 GO:0071400; P:cellular response to oleic acid; ISS:BHF-UCL.
 GO:0035356; P:cellular triglyceride homeostasis; ISS:BHF-UCL.
 GO:0042632; P:cholesterol homeostasis; ISS:BHF-UCL.
 GO:0046339; P:diacylglycerol metabolic process; IDA:BHF-UCL.
 GO:0060613; P:fat pad development; ISS:BHF-UCL.
 GO:0055089; P:fatty acid homeostasis; ISS:BHF-UCL.
 GO:0006071; P:glycerol metabolic process; IEA:UniProtKB-KW.
 GO:0046474; P:glycerophospholipid biosynthetic process; TAS:Reactome.
 GO:0019915; P:lipid storage; ISS:BHF-UCL.
 GO:0035336; P:long-chain fatty-acyl-CoA metabolic process; IDA:BHF-UCL.
 GO:0034383; P:low-density lipoprotein particle clearance; ISS:BHF-UCL.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome.
 GO:0019432; P:triglyceride biosynthetic process; IDA:UniProtKB. 
Interpro
 IPR007130; DAGAT. 
Pfam
 PF03982; DAGAT 
SMART
  
PROSITE
  
PRINTS