| Tag | Content |
|---|
| CPLM ID | CPLM-019069 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Solute carrier organic anion transporter family member 4A1 |
Protein Synonyms/Alias | OATP4A1; Colon organic anion transporter; Organic anion transporter polypeptide-related protein 1; OATP-RP1; OATPRP1; POAT; Organic anion-transporting polypeptide E; OATP-E; Sodium-independent organic anion transporter E; Solute carrier family 21 member 12 |
Gene Name | SLCO4A1 |
Gene Synonyms/Alias | OATP1; OATP4A1; OATPE; SLC21A12 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 353 | AAEMHQLKDSSRGEA | ubiquitination | [1] | | 367 | ASNPDFGKTIRDLPL | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Mediates the Na(+)-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and of estrone-3-sulfate and taurocholate. |
Sequence Annotation | DOMAIN 498 555 Kazal-like.
MOD_RES 34 34 Phosphoserine.
MOD_RES 37 37 Phosphothreonine.
MOD_RES 40 40 Phosphoserine.
MOD_RES 43 43 Phosphoserine.
MOD_RES 46 46 Phosphoserine.
MOD_RES 50 50 Phosphoserine.
CARBOHYD 499 499 N-linked (GlcNAc...) (Potential).
CARBOHYD 557 557 N-linked (GlcNAc...) (Potential).
DISULFID 504 530 By similarity.
DISULFID 508 519 By similarity.
DISULFID 510 534 By similarity. |
Keyword | Alternative splicing; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Ion transport; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 722 AA |
Protein Sequence | MPLHQLGDKP LTFPSPNSAM ENGLDHTPPS RRASPGTPLS PGSLRSAAHS PLDTSKQPLC 60
QLWAEKHGAR GTHEVRYVSA GQSVACGWWA FAPPCLQVLN TPKGILFFLC AAAFLQGMTV 120
NGFINTVITS LERRYDLHSY QSGLIASSYD IAACLCLTFV SYFGGSGHKP RWLGWGVLLM 180
GTGSLVFALP HFTAGRYEVE LDAGVRTCPA NPGAVCADST SGLSRYQLVF MLGQFLHGVG 240
ATPLYTLGVT YLDENVKSSC SPVYIAIFYT AAILGPAAGY LIGGALLNIY TEMGRRTELT 300
TESPLWVGAW WVGFLGSGAA AFFTAVPILG YPRQLPGSQR YAVMRAAEMH QLKDSSRGEA 360
SNPDFGKTIR DLPLSIWLLL KNPTFILLCL AGATEATLIT GMSTFSPKFL ESQFSLSASE 420
AATLFGYLVV PAGGGGTFLG GFFVNKLRLR GSAVIKFCLF CTVVSLLGIL VFSLHCPSVP 480
MAGVTASYGG SLLPEGHLNL TAPCNAACSC QPEHYSPVCG SDGLMYFSLC HAGCPAATET 540
NVDGQKVSGA AAYRPCPPLD PGKGPPCLPL VIGAIVGLPR CTETVAVSLR IFPLVLAMHC 600
REMHFNLSEK APPSGFHIRC NFLYIPQQHS CTNGNSTVSW GRVCACPELS LQHPEAELCR 660
S 661 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; TAS:Reactome. GO:0005215; F:transporter activity; IEA:InterPro. GO:0043252; P:sodium-independent organic anion transport; TAS:Reactome. GO:0055085; P:transmembrane transport; TAS:Reactome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |