| Tag | Content |
|---|
| CPLM ID | CPLM-018050 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Elongator complex protein 5 |
Protein Synonyms/Alias | Dermal papilla-derived protein 6; S-phase 2 protein |
Gene Name | ELP5 |
Gene Synonyms/Alias | C17orf81; DERP6; HSPC002; MSTP071 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 48 | LLKALVKKSALCGEQ | ubiquitination | [1] | | 94 | RDPLNWSKTEEAFPG | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration (By similarity). May be involved in TP53-mediated transcriptional regulation. |
Sequence Annotation | |
Keyword | Alternative splicing; Complete proteome; Cytoplasm; Nucleus; Polymorphism; Reference proteome; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 316 AA |
Protein Sequence | MTPSEGARAG TGRELEMLDS LLALGGLVLL RDSVEWEGRS LLKALVKKSA LCGEQVHILG 60
CEVSEEEFRE GFDSDINNRL VYHDFFRDPL NWSKTEEAFP GGPLGALRAM CKRTDPVPVT 120
IALDSLSWLL LRLPCTTLCQ VLHAVSHQDS CPGDSSSVGK VSVLGLLHEE LHGPGPVGAL 180
SSLAQTEVTL GGTMGQASAH ILCRRPRQRP TDQTQWFSIL PDFSLDLQEG PSVESQPYSD 240
PHIPPVHPLY LQVDPTTHLT FNLHLSKKER EARDSLILPF QFSSEKQQAL LRPRPGQATS 300
HIFYEPDAYD DLDQEDPDDD LDI 323 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:UniProtKB. GO:0033588; C:Elongator holoenzyme complex; IDA:UniProtKB. GO:0005634; C:nucleus; IDA:UniProtKB. GO:0030335; P:positive regulation of cell migration; ISS:UniProtKB. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |