UniProt Accession

 HOGA1_MOUSE; Q9DCU9; Q91W74; Q9CY60 

Genbank Protein ID

 AK002457; AK010857; BC016430 

Genbank Nucleotide ID

 BAB22114.1; BAB27226.1; AAH16430.1 

Protein Name

 Probable 4-hydroxy-2-oxoglutarate aldolase, mitochondrial 

Protein Synonyms/Alias

 Dihydrodipicolinate synthase-like; DHDPS-like protein; Probable 2-keto-4-hydroxyglutarate aldolase; Probable KHG-aldolase 

Gene Name

 Hoga1 

Gene Synonyms/Alias

 Dhdpsl 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
96	RVRQAIPKDKFLIAG	acetylation	[1]
190	HPNIIGLKDSGGDVT	acetylation	[2]

Reference

 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753] 

Functional Description

 Catalyzes the final step in the metabolic pathway of hydroxyproline (By similarity). 

Sequence Annotation

 REGION 71 72 Substrate binding (By similarity).
 ACT_SITE 190 190 Schiff-base intermediate with substrate  

Keyword

 Complete proteome; Lyase; Mitochondrion; Reference proteome; Schiff base; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 321 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0008700; F:4-hydroxy-2-oxoglutarate aldolase activity; ISS:UniProtKB.
 GO:0019470; P:4-hydroxyproline catabolic process; IEA:Compara.
 GO:0009436; P:glyoxylate catabolic process; ISS:UniProtKB.
 GO:0033609; P:oxalate metabolic process; IEA:Compara.
 GO:0042866; P:pyruvate biosynthetic process; IEA:Compara. 

Interpro

 IPR013785; Aldolase_TIM.
 IPR002220; Dihydrodipicolinate_synth-like.
 IPR020625; Dihydrodipicolinate_synth_AS. 

Pfam

 PF00701; DHDPS 

SMART

  

PROSITE

 PS00665; DHDPS_1
 PS00666; DHDPS_2 

PRINTS

 PR00146; DHPICSNTHASE.