| Tag | Content |
|---|
| CPLM ID | CPLM-023152 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Bromodomain and PHD finger-containing protein 3 |
Protein Synonyms/Alias | |
Gene Name | BRPF3 |
Gene Synonyms/Alias | KIAA1286 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 105 | KKKESCSKHASGTSF | acetylation | [1] | | 447 | SLKGVPKKSKMSLKQ | acetylation | [1] | | 449 | KGVPKKSKMSLKQKI | acetylation | [1] | | 546 | DEKTSAVKEELKYWQ | acetylation | [1] | | 554 | EELKYWQKLRHDLER | acetylation | [1] | | 671 | NCMKYNAKDTIFHRA | acetylation | [1] |
|
Reference | [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions. Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M. Science. 2009 Aug 14;325(5942):834-40. [ PMID: 19608861] |
Functional Description | Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. |
Sequence Annotation | DOMAIN 606 676 Bromo.
DOMAIN 1076 1159 PWWP.
ZN_FING 212 262 PHD-type.
MOD_RES 17 17 Phosphoserine.
MOD_RES 400 400 Phosphoserine.
MOD_RES 403 403 Phosphoserine.
MOD_RES 447 447 N6-acetyllysine.
MOD_RES 449 449 N6-acetyllysine.
MOD_RES 671 671 N6-acetyllysine.
MOD_RES 900 900 Phosphoserine.
MOD_RES 962 962 Phosphoserine.
MOD_RES 965 965 Phosphoserine. |
Keyword | 3D-structure; Acetylation; Bromodomain; Chromatin regulator; Complete proteome; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1205 AA |
Protein Sequence | MRKPRRKSRQ NAEGRRSPSP YSLKCSPTRE TLTYAQAQRI VEVDIDGRLH RISIYDPLKI 60
ITEDELTAQD ITECNSNKEN SEQPQFPGKS KKPSSKGKKK ESCSKHASGT SFHLPQPSFR 120
MVDSGIQPEA PPLPAAYYRY IEKPPEDLDA EVEYDMDEED LAWLDMVNEK RRVDGHSLVS 180
ADTFELLVDR LEKESYLESR SSGAQQSLID EDAFCCVCLD DECHNSNVIL FCDICNLAVH 240
QECYGVPYIP EGQWLCRCCL QSPSRPVDCI LCPNKGGAFK QTSDGHWAHV VCAIWIPEVC 300
FANTVFLEPI EGIDNIPPAR WKLTCYICKQ KGLGAAIQCH KVNCYTAFHV TCAQRAGLFM 360
KIEPMRETSL NGTIFTVRKT AYCEAHSPPG AATARRKGDS PRSISETGDE EGLKEGDGEE 420
EEEEEVEEEE QEAQGGVSGS LKGVPKKSKM SLKQKIKKEP EEAGQDTPST LPMLAVPQIP 480
SYRLNKICSG LSFQRKNQFM QRLHNYWLLK RQARNGVPLI RRLHSHLQSQ RNAEQREQDE 540
KTSAVKEELK YWQKLRHDLE RARLLIELIR KREKLKREQV KVQQAAMELE LMPFNVLLRT 600
TLDLLQEKDP AHIFAEPVNL SEVPDYLEFI SKPMDFSTMR RKLESHLYRT LEEFEEDFNL 660
IVTNCMKYNA KDTIFHRAAV RLRDLGGAIL RHARRQAENI GYDPERGTHL PESPKLEDFY 720
RFSWEDVDNI LIPENRAHLS PEVQLKELLE KLDLVSAMRS SGARTRRVRL LRREINALRQ 780
KLAQPPPPQP PSLNKTVSNG ELPAGPQGDA AVLEQALQEE PEDDGDRDDS KLPPPPTLEP 840
TGPAPSLSEQ ESPPEPPTLK PINDSKPPSR FLKPRKVEED ELLEKSPLQL GNEPLQRLLS 900
DNGINRLSLM APDTPAGTPL SGVGRRTSVL FKKAKNGVKL QRSPDRVLEN GEDHGVAGSP 960
ASPASIEEER HSRKRPRSRS CSESEGERSP QQEEETGMTN GFGKHTESGS DSECSLGLSG 1020
GLAFEACSGL TPPKRSRGKP ALSRVPFLEG VNGDSDYNGS GRSLLLPFED RGDLEPLELV 1080
WAKCRGYPSY PALIIDPKMP REGLLHNGVP IPVPPLDVLK LGEQKQAEAG EKLFLVLFFD 1140
NKRTWQWLPR DKVLPLGVED TVDKLKMLEG RKTSIRKSVQ VAYDRAMIHL SRVRGPHSFV 1200
TSSYL 1205 |
Gene Ontology | GO:0005829; C:cytosol; TAS:Reactome. GO:0005576; C:extracellular region; TAS:Reactome. GO:0070776; C:MOZ/MORF histone acetyltransferase complex; IDA:UniProtKB. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0043966; P:histone H3 acetylation; IDA:UniProtKB. GO:0030168; P:platelet activation; TAS:Reactome. GO:0002576; P:platelet degranulation; TAS:Reactome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |