UniProt Accession

 CNBP1_MOUSE; Q9JJN6 

Genbank Protein ID

 AB021261; AK003595; AK009066; AK036181; AK048258; BC038253 

Genbank Nucleotide ID

 BAB03457.1; BAB22883.1; BAB26052.1; BAC29336.1; BAC33287.1; AAH38253.1 

Protein Name

 Beta-catenin-interacting protein 1 

Protein Synonyms/Alias

 Inhibitor of beta-catenin and Tcf-4 

Gene Name

 Ctnnbip1 

Gene Synonyms/Alias

 Catnbip1; Icat 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
19	EEMYIQQKVRVLLML	acetylation	[1]
19	EEMYIQQKVRVLLML	ubiquitination	[2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Prevents the interaction between CTNNB1 and TCF family members, and acts as negative regulator of the Wnt signaling pathway. 

Sequence Annotation

  

Keyword

 Complete proteome; Cytoplasm; Nucleus; Reference proteome; Wnt signaling pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 81 AA 

Protein Sequence

Gene Ontology

 GO:0030877; C:beta-catenin destruction complex; IBA:RefGenome.
 GO:0005829; C:cytosol; IBA:RefGenome.
 GO:0005634; C:nucleus; IBA:RefGenome.
 GO:0009952; P:anterior/posterior pattern specification; IMP:MGI.
 GO:0001658; P:branching involved in ureteric bud morphogenesis; IMP:MGI.
 GO:0043392; P:negative regulation of DNA binding; IDA:BHF-UCL.
 GO:0072201; P:negative regulation of mesenchymal cell proliferation; IEA:Compara.
 GO:0032091; P:negative regulation of protein binding; IEA:Compara.
 GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity; IDA:BHF-UCL.
 GO:0048662; P:negative regulation of smooth muscle cell proliferation; IMP:BHF-UCL.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
 GO:0060633; P:negative regulation of transcription initiation from RNA polymerase II promoter; IDA:BHF-UCL.
 GO:0030178; P:negative regulation of Wnt receptor signaling pathway; IDA:MGI.
 GO:0045657; P:positive regulation of monocyte differentiation; IEA:Compara.
 GO:0045669; P:positive regulation of osteoblast differentiation; IEA:Compara.
 GO:0002528; P:regulation of vascular permeability involved in acute inflammatory response; IEA:Compara.
 GO:0016055; P:Wnt receptor signaling pathway; IPI:MGI. 

Interpro

 IPR009428; ICAT. 

Pfam

 PF06384; ICAT 

SMART

  

PROSITE

  

PRINTS