CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000348
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein transport protein Sec16A 
Protein Synonyms/Alias
 SEC16 homolog A 
Gene Name
 SEC16A 
Gene Synonyms/Alias
 KIAA0310; SEC16; SEC16L 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
444KSHLVGVKPFEADRAacetylation[1]
1919RPGQAAKKETKEPKKacetylation[2]
1925KKETKEPKKGESWFFacetylation[2]
1926KETKEPKKGESWFFRacetylation[2]
Reference
 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Defines endoplasmic reticulum exit sites (ERES) and is required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for normal transitional endoplasmic reticulum (tER) organization. 
Sequence Annotation
 REGION 924 1227 Required for endoplasmic reticulum
 REGION 1928 2179 Required for interaction with SEC23A.
 MOD_RES 136 136 Phosphoserine.
 MOD_RES 391 391 Phosphoserine.
 MOD_RES 411 411 Phosphoserine.
 MOD_RES 414 414 Phosphoserine.
 MOD_RES 415 415 Phosphothreonine.
 MOD_RES 417 417 Phosphoserine.
 MOD_RES 891 891 Phosphoserine.
 MOD_RES 1149 1149 Phosphoserine.
 MOD_RES 1178 1178 Phosphoserine.
 MOD_RES 1181 1181 Phosphoserine.
 MOD_RES 1184 1184 Phosphoserine.
 MOD_RES 1786 1786 Phosphoserine.
 MOD_RES 1844 1844 Phosphoserine.
 MOD_RES 1864 1864 Phosphoserine.
 MOD_RES 1876 1876 Phosphothreonine.
 MOD_RES 1895 1895 Phosphoserine.
 MOD_RES 1905 1905 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus; Membrane; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2179 AA 
Protein Sequence
MPGLDRPLSR QNPHDGVVTP AASPSLPQPG LQMPGQWGPV QGGPQPSGQH RSPCPEGPVP 60
SGVPCATSVP HFPTPSILHQ GPGHEQHSPL VAPPAALPSD GRDEVSHLQS GSHLANNSDP 120
ESTFRQNPRI VNHWASPELR QNPGVKNEHR PASALVNPLA RGDSPENRTH HPLGAGAGSG 180
CAPLEADSGA SGALAMFFQG GETENEENLS SEKAGLSGQA DFDDFCSSPG LGRPPAPTHV 240
GAGSLCQALL PGPSNEAAGD VWGDTASTGV PDASGSQYEN VENLEFVQNQ EVLPSEPLNL 300
DPSSPSDQFR YGPLPGPAVP RHGAVCHTGA PDATLHTVHP DSVSSSYSSR SHGRLSGSAR 360
PQELVGTFIQ QEVGKPEDEA SGSFFKQIDS SPVGGETDET TVSQNYRGSV SQPSTPSPPK 420
PTGIFQTSAN SSFEPVKSHL VGVKPFEADR ANVVGEVRET CVRQKQCRPA AALPDASPGN 480
LEQPPDNMET LCAPQVCPLP LNSTTEAVHM LPHAGAPPLD TVYPAPEKRP SARTQGPVKC 540
ESPATTLWAQ SELPDFGGNV LLAPAAPALY VCAKPQPPVV QPPEEAMSGQ QSRNPSSAAP 600
VQSRGGIGAS ENLENPPKMG EEEALQSQAS SGYASLLSSP PTESLQNPPV LIAQPDHSYN 660
LAQPINFSVS LSNSHEKNQS WREALVGDRP AVSSWALGGD SGENTSLSGI PTSSVLSLSL 720
PSSVAQSNFP QGSGASEMVS NQPANLLVQP PSQPVPENLV PESQKDRKAG SALPGFANSP 780
AGSTSVVLVP PAHGTLVPDG NKANHSSHQE DTYGALDFTL SRTLENPVNV YNPSHSDSLA 840
SQQSVASHPR QSGPGAPNLD RFYQQVTKDA QGQPGLERAQ QELVPPQQQA SPPQLPKAMF 900
SELSNPESLP AQGQAQNSAQ SPASLVLVDA GQQLPPRPPQ SSSVSLVSSG SGQAAVPSEQ 960
PWPQPVPALA PGPPPQDLAA YYYYRPLYDA YQPQYSLPYP PEPGAASLYY QDVYSLYEPR 1020
YRPYDGAASA YAQNYRYPEP ERPSSRASHS SERPPPRQGY PEGYYSSKSG WSSQSDYYAS 1080
YYSSQYDYGD PGHWDRYHYS ARVRDPRTYD RRYWCDAEYD AYRREHSAFG DRPEKRDNNW 1140
RYDPRFTGSF DDDPDPHRDP YGEEVDRRSV HSEHSARSLH SAHSLASRRS SLSSHSHQSQ 1200
IYRSHNVAAG SYEAPLPPGS FHGDFAYGTY RSNFSSGPGF PEYGYPADTV WPAMEQVSSR 1260
PTSPEKFSVP HVCARFGPGG QLIKVIPNLP SEGQPALVEV HSMEALLQHT SEQEEMRAFP 1320
GPLAKDDTHK VDVINFAQNK AMKCLQNENL IDKESASLLW NFIVLLCRQN GTVVGTDIAE 1380
LLLRDHRTVW LPGKSPNEAN LIDFTNEAVE QVEEEESGEA QLSFLTGGPA AAASSLERET 1440
ERFRELLLYG RKKDALESAM KNGLWGHALL LASKMDSRTH ARVMTRFANS LPINDPLQTV 1500
YQLMSGRMPA ASTCCGDEKW GDWRPHLAMV LSNLNNNMDV ESRTMATMGD TLASRGLLDA 1560
AHFCYLMAQA GFGVYTKKTT KLVLIGSNHS LPFLKFATNE AIQRTEAYEY AQSLGAETCP 1620
LPSFQVFKFI YSCRLAEMGL ATQAFHYCEA IAKSILTQPH LYSPVLISQL VQMASQLRLF 1680
DPQLKEKPEE ESLAAPTWLV HLQQVERQIK EGAGVWHQDG ALPQQCPGTP SSEMEQLDRP 1740
GLSQPGALGI ANPLLAVPAP SPEHSSPSVR LLPSAPQTLP DGPLASPARV PMFPVPLPPG 1800
PLEPGPGCVT PGPALGFLEP SGPGLPPGVP PLQERRHLLQ EARSPDPGIV PQEAPVGNSL 1860
SELSEENFDG KFANLTPSRT VPDSEAPPGW DRADSGPTQP PLSLSPAPET KRPGQAAKKE 1920
TKEPKKGESW FFRWLPGKKK TEAYLPDDKN KSIVWDEKKN QWVNLNEPEE EKKAPPPPPT 1980
SMPKTVQAAP PALPGPPGAP VNMYSRRAAG TRARYVDVLN PSGTQRSEPA LAPADFVAPL 2040
APLPIPSNLF VPTPDAEEPQ LPDGTGREGP AAARGLANPE PAPEPKVLSS AASLPGSELP 2100
SSRPEGSQGG ELSRCSSMSS LSREVSQHFN QAPGDLPAAG GPPSGAMPFY NPAQLAQACA 2160
TSGSSRLGRI GQRKHLVLN 2179 
Gene Ontology
 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0048208; P:COPII vesicle coating; IEA:InterPro.
 GO:0007029; P:endoplasmic reticulum organization; IDA:UniProtKB.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 
Interpro
 IPR024880; Sec16.
 IPR024340; Sec16_CCD. 
Pfam
 PF12932; Sec16 
SMART
  
PROSITE
  
PRINTS