UniProt Accession

 THOC7_BOVIN; Q3SZ60 

Genbank Protein ID

 BC103118 

Genbank Nucleotide ID

 AAI03119.1 

Protein Name

 THO complex subunit 7 homolog 

Protein Synonyms/Alias

  

Gene Name

 THOC7 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Bos taurus (Bovine) 

NCBI Taxa ID

 9913 

Lysine Modification

Position	Peptide	Type	References
86	ENYEKIYKEIECSIA	ubiquitination	[1]
98	SIAGAHEKIAECKKQ	ubiquitination	[1]
110	KKQILQAKRIRKNRQ	ubiquitination	[1]
114	LQAKRIRKNRQEYDA	ubiquitination	[1]
144	KELEALGKELEHLSH	ubiquitination	[1]
153	LEHLSHIKESVEDKL	ubiquitination	[1]
159	IKESVEDKLELRRKQ	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. DDX39B functions as a bridge between ALYREF/THOC4 and the THO complex (By similarity). 

Sequence Annotation

 REGION 50 137 Interaction with THOC5 (By similarity).
 REGION 105 204 Interaction with NIF3L1 (By similarity).
 MOD_RES 2 2 N-acetylglycine (By similarity).
 MOD_RES 36 36 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Coiled coil; Complete proteome; Cytoplasm; mRNA processing; mRNA splicing; mRNA transport; Nucleus; Reference proteome; RNA-binding; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 204 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0000445; C:THO complex part of transcription export complex; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. 

Interpro

 IPR018018; THOC7.
 IPR008501; THOC7/Mft1. 

Pfam

 PF05615; THOC7 

SMART

  

PROSITE

  

PRINTS