UniProt Accession

 SAHH2_HUMAN; O43865; B4E168; Q2TAJ6; Q502W8; Q5VSM0; Q6P171; Q96PK4; Q9UG84 

Genbank Protein ID

 AF315687; AL036027; AK303690; AK316110; AL049954; AL772411; AL772411; CH471122; BC007576; BC010681; BC016942; BC065254; BC095476; BC110896; BI460083; U82761; AU279527; T19009; BK005418; BK005417 

Genbank Nucleotide ID

 AAL26869.1; BAG64680.1; BAH14481.1; CAB43223.2; CAH70965.1; CAH70966.1; EAW56426.1; AAH07576.3; AAH10681.3; AAH16942.3; AAH65254.2; AAH95476.2; AAI10897.2; AAC01960.1; DAA05763.1; DAA05762.1 

Protein Name

 Putative adenosylhomocysteinase 2 

Protein Synonyms/Alias

 AdoHcyase 2; DC-expressed AHCY-like molecule; S-adenosyl-L-homocysteine hydrolase 2; S-adenosylhomocysteine hydrolase-like protein 1 

Gene Name

 AHCYL1 

Gene Synonyms/Alias

 DCAL; XPVKONA 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
53	DDMQEFTKFPTKTGR	ubiquitination	[1]
100	EKQQTNSKGSSNFCV	ubiquitination	[2]
267	HRLYQLSKAGKLCVP	ubiquitination	[2]
270	YQLSKAGKLCVPAMN	ubiquitination	[2]
284	NVNDSVTKQKFDNLY	ubiquitination	[2]
286	NDSVTKQKFDNLYCC	ubiquitination	[2]
359	MDGFRVVKLNEVIRQ	ubiquitination	[2]
389	REHLDRMKNSCIVCN	ubiquitination	[1, 2]
432	HVIWPDGKRVVLLAE	ubiquitination	[2]
478	NAPEGRYKQDVYLLP	ubiquitination	[2]
487	DVYLLPKKMDEYVAS	ubiquitination	[2, 3]

Reference

 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

  

Sequence Annotation

 NP_BIND 318 322 NAD.
 NP_BIND 397 399 NAD.
 REGION 65 92 PEST (By similarity).
 REGION 281 448 NAD binding (By similarity).
 REGION 520 530 PDZ-binding (By similarity).
 BINDING 155 155 Substrate (By similarity).
 BINDING 229 229 Substrate (By similarity).
 BINDING 254 254 Substrate (By similarity).
 BINDING 284 284 Substrate (By similarity).
 BINDING 288 288 Substrate (By similarity).
 BINDING 341 341 NAD.
 BINDING 376 376 NAD.
 MOD_RES 2 2 N-acetylserine.
 MOD_RES 2 2 Phosphoserine.
 MOD_RES 82 82 Phosphothreonine (By similarity).
 MOD_RES 84 84 Phosphoserine (By similarity).
 MOD_RES 85 85 Phosphoserine (By similarity).
 MOD_RES 391 391 Phosphoserine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Endoplasmic reticulum; Hydrolase; NAD; One-carbon metabolism; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 530 AA 

Protein Sequence

Gene Ontology

 GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
 GO:0004013; F:adenosylhomocysteinase activity; IEA:EC.
 GO:0006378; P:mRNA polyadenylation; IEA:Compara.
 GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
 GO:0010765; P:positive regulation of sodium ion transport; IEA:Compara.
 GO:0006611; P:protein export from nucleus; IEA:Compara.
 GO:0044070; P:regulation of anion transport; IEA:Compara.
 GO:0032412; P:regulation of ion transmembrane transporter activity; IEA:Compara.
 GO:0031440; P:regulation of mRNA 3'-end processing; IEA:Compara. 

Interpro

 IPR000043; Adenosylhomocysteinase.
 IPR015878; Ado_hCys_hydrolase_NAD-bd.
 IPR016040; NAD(P)-bd_dom.
 IPR020082; S-Ado-L-homoCys_hydrolase_CS. 

Pfam

 PF05221; AdoHcyase
 PF00670; AdoHcyase_NAD 

SMART

 SM00996; AdoHcyase
 SM00997; AdoHcyase_NAD 

PROSITE

 PS00738; ADOHCYASE_1
 PS00739; ADOHCYASE_2 

PRINTS