CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027532
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein Slc25a1 
Protein Synonyms/Alias
 Solute carrier family 25 (Mitochondrial carrier, citrate transporter), member 1 
Gene Name
 Slc25a1 
Gene Synonyms/Alias
 mCG_131850 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
97LLYGSIPKAAVRFGMacetylation[1, 2, 3, 4]
149PMETIKVKFIHDQTSacetylation[2]
160DQTSSNPKYRGFFHGacetylation[2, 5]
160DQTSSNPKYRGFFHGubiquitination[6]
178IIREQGLKGTYQGLTubiquitination[6]
190GLTATVLKQGSNQAIacetylation[5]
255MQGLEAHKYRNTLDCacetylation[2]
265NTLDCGLKILKNEGPacetylation[2]
265NTLDCGLKILKNEGPubiquitination[6]
268DCGLKILKNEGPKAFacetylation[2, 5]
277EGPKAFYKGTVPRLGacetylation[2]
Reference
 [1] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [5] Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.
 Kim SC, Sprung R, Chen Y, Xu Y, Ball H, Pei J, Cheng T, Kho Y, Xiao H, Xiao L, Grishin NV, White M, Yang XJ, Zhao Y.
 Mol Cell. 2006 Aug;23(4):607-18. [PMID: 16916647]
 [6] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 311 AA 
Protein Sequence
MAAPRGPRAL SAAAPGSGKP KLTHPGKAIL AGGLAGGIEI CITFPTEYVK TQLQLDERAN 60
PPRYRGIGDC VRQTVRSHGV LGLYRGLSSL LYGSIPKAAV RFGMFEFLSN HMRDAQGRLD 120
SRRGLLCGLG AGVAEAVVVV CPMETIKVKF IHDQTSSNPK YRGFFHGVRE IIREQGLKGT 180
YQGLTATVLK QGSNQAIRFF VMTSLRNWYQ GDNHNKPMNP LITGVFGATA GAASVFGNTP 240
LDVIKTRMQG LEAHKYRNTL DCGLKILKNE GPKAFYKGTV PRLGRVCLDV AIVFIIYDEV 300
VKLLNKVWKT D 311 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005743; C:mitochondrial inner membrane; IDA:MGI.
 GO:0055085; P:transmembrane transport; IEA:InterPro. 
Interpro
 IPR002067; Mit_carrier.
 IPR018108; Mitochondrial_sb/sol_carrier.
 IPR023395; Mt_carrier_dom. 
Pfam
 PF00153; Mito_carr 
SMART
  
PROSITE
 PS50920; SOLCAR 
PRINTS
 PR00926; MITOCARRIER.