CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-027613
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 GH24511p 
Protein Synonyms/Alias
 Ubiquitin activating enzyme 1 
Gene Name
 Uba1 
Gene Synonyms/Alias
 CG1782; Dmel_CG1782 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
935KVKVPEFKPRSGVKIacetylation[1]
975KIISELLKNADKSSKacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Ligase; Nucleotide-binding; Reference proteome; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1191 AA 
Protein Sequence
MSSGQQLMAD SPACSSSDHS PLAKKRRLEL LGDGVGAMGM EEEEAGGATS SSSSNNYENH 60
DKAGGVDISG KCQSKTTSEH QLELCVSSST SDTCGVNAAA KRAEKQKLKQ SQGSGDDVST 120
SSAVEKEGSK RPEKRNYLNT TTIESQEASS SASATSNSNN NVSSSNNNSN NSTNNRQLEG 180
SSNMAGNSAA AGGDIDESLY SRQLYVLGHD AMRRMANSDI LLSGLGGLGL EIAKNVILGG 240
VKSITLHDTA TCGLHDLSSQ FYLTEADIGK NRAEASCAQL AELNNYVRTV SHTGPLTEEF 300
LRKFRVVVLT NSDGEEQQRI AKFAHENGIA LIIAETRGLF AKVFCDFGES FTIYDQDGTQ 360
PISTMIASIT HDAQGVVTCL DETRHGFNDG DYVTFSEVQG MQELNGCQPL KITVLGPYTF 420
SIGDTSKFGE YKSGGVATQV KMPKTISFKP LAQATEEPEF LISDFAKLDS PATLHVAFNA 480
LSCYRKAHNG ALPRPWNEED ANSFLEVVRA SSNAEVDEKL VLQFAKICSG NTCPLDAAVG 540
GIVAQEVLKA CSGKFTPIYQ WLYFDALECL PTEGVEEADA QPVGSRYDSQ IAIFGKKFQE 600
KLADSKWFIV GAGAIGCELL KNFGMLGLGT GNGQIFVTDM DLIEKSNLNR QFLFRPHDVQ 660
KPKSMTAADA IKRMNPEVNV TAYELRVGAE TEKVFSEDFF GKLDGVANAL DNVDARIYMD 720
RKCIFNRIPL VETGTLGTLG NVQVIVPFAT ESYSSSQDPP EKSIPICTLK NFPNAIEHTL 780
QWARDAFEGV FKQSAENAAQ YIADPQFTER IAKLPGIQPL EILDSIKKAL IDDKPKSFAH 840
CVEWARLYWE DQYVNQIKQL LFNFPPDQIT SSGQPFWSGP KRCPDPLVFD VNDPMHLDFI 900
YAAANLRAEV YGIEQVRNRE TIAELVQKVK VPEFKPRSGV KIETNEAAAA ASANNFDDGE 960
LDQDRVDKII SELLKNADKS SKITPLEFEK DDDSNLHMDF IVACSNLRAA NYKIPPADRH 1020
KSKLIAGKII PAIATTTSVL SGLAVLEVIK LIVGHRDLVK FKNGFANLAL PFMAFSEPLP 1080
AAKNTYYGKE WTLWDRFEVT GELSLQEFLN YFEENEKLKI TMLSQGVSML YSFFMPKAKC 1140
SERLPLPMSE VVRRVSKRRL EPHERSLVFE ICCNDVDGED VEVPYVRYTL P 1191 
Gene Ontology
 GO:0030425; C:dendrite; IMP:FlyBase.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008641; F:small protein activating enzyme activity; IEA:InterPro.
 GO:0004842; F:ubiquitin-protein ligase activity; IEA:EC.
 GO:0008283; P:cell proliferation; IMP:FlyBase.
 GO:0019915; P:lipid storage; IDA:FlyBase.
 GO:0016319; P:mushroom body development; IMP:FlyBase.
 GO:0016322; P:neuron remodeling; IMP:FlyBase.
 GO:0016567; P:protein ubiquitination; IMP:FlyBase.
 GO:0040008; P:regulation of growth; IMP:FlyBase.
 GO:0043067; P:regulation of programmed cell death; IMP:FlyBase.
 GO:0046578; P:regulation of Ras protein signal transduction; IMP:FlyBase. 
Interpro
 IPR009036; Molybdenum_cofac_synth_MoeB.
 IPR016040; NAD(P)-bd_dom.
 IPR000594; ThiF_NAD_FAD-bd.
 IPR018965; Ub-activating_enz_e1_C.
 IPR023280; Ub-like_act_enz_cat_cys_dom.
 IPR000127; UBact_repeat.
 IPR019572; Ubiquitin-activating_enzyme.
 IPR018075; UBQ-activ_enz_E1.
 IPR018074; UBQ-activ_enz_E1_AS.
 IPR000011; UBQ/SUMO-activ_enz_E1-like. 
Pfam
 PF00899; ThiF
 PF09358; UBA_e1_C
 PF10585; UBA_e1_thiolCys
 PF02134; UBACT 
SMART
 SM00985; UBA_e1_C 
PROSITE
 PS00536; UBIQUITIN_ACTIVAT_1
 PS00865; UBIQUITIN_ACTIVAT_2 
PRINTS
 PR01849; UBIQUITINACT.