CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000957
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tudor domain-containing protein 6 
Protein Synonyms/Alias
 Antigen NY-CO-45; Cancer/testis antigen 41.2; CT41.2 
Gene Name
 TDRD6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
1493ELSTQVIKSASSKSVacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Involved in spermiogenesis, chromatoid body formation and for proper precursor and mature miRNA expression (By similarity). 
Sequence Annotation
 DOMAIN 65 120 Tudor 1.
 DOMAIN 310 369 Tudor 2.
 DOMAIN 536 593 Tudor 3.
 DOMAIN 816 875 Tudor 4.
 DOMAIN 1033 1088 Tudor 5.
 DOMAIN 1352 1411 Tudor 6.
 DOMAIN 1567 1626 Tudor 7.
 DOMAIN 2026 2084 Tudor 8.  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Developmental protein; Differentiation; Polymorphism; Reference proteome; Repeat; Spermatogenesis. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2096 AA 
Protein Sequence
MCSTPGMPAP GASLALRVSF VDVHPDVIPV QLWGLVGERR GEYLRLSREI QEAAATRGQW 60
ALGSASASPG ELCLVQVGLL WHRCRVVSRQ AQESRVFLLD EGRTITAGAG SLAPGRREFF 120
NLPSEVLGCV LAGLVPAGCG AGSGEPPQHW PADAVDFLSN LQGKEVHGCV LDVLLLHRLV 180
LLEVPDVFQQ MRELGLARRV PDSLFRSLLE RYLTAATASV GSGVPVLSRV PLKQKQPGLD 240
YFYPQLQLGV TEAVVITQVC HPHRIHCQLR SVSQEIHRLS ESMAQVYRGS TGTGDENSTS 300
ATWEEREESP DKPGSPCASC GLDGHWYRAL LLETFRPQRC AQVLHVDYGR KELVSCSSLR 360
YLLPEYFRMP VVTYPCALYG LWDGGRGWSR SQVGDLKTLI LGKAVNAKIE FYCSFEHVYY 420
VSLYGEDGIN LNRVFGVQSC CLADRVLQSQ ATEEEEPETS QSQSPAEEVD EEISLPALRS 480
IRLKMNAFYD AQVEFVKNPS EFWIRLRKHN VTFSKLMRRM CGFYSSASKL DGVVLKPEPD 540
DLCCVKWKEN GYYRAIVTKL DDKSVDVFLV DRGNSENVDW YDVRMLLPQF RQLPILAVKC 600
TLADIWPLGK TWSQEAVSFF KKTVLHKELV IHILDKQDHQ YVIEILDESR TGEENISKVI 660
AQAGYAKYQE FETKENILVN AHSPGHVSNH FTTESNKIPF AKTGEGEQKA KRENKTTSVS 720
KALSDTTVVT NGSTELVVQE KVKRASVYFP LMQNCLEIKP GSSSKGELEV GSTVEVRVSY 780
VENPGYFWCQ LTRNIQGLKT LMSDIQYYCK NTAAPHQRNT LACLAKRTVN RQWSRALISG 840
IQSVEHVNVT FVDYGDREMV SVKNIYSISE EFLKVKAQAF RCSLYNLIQP VGQNPFVWDV 900
KAIQAFNEFI DNAWQKNLEL KCTIFALASI NEELFNIVDL LTPFQSACHF LVEKRLARPV 960
KLQKPLESSV QLHSYFYSTH DMKIGSEELV YITHIDDPWT FYCQLARNAN ILEQLSCSIT 1020
QLSKVLLNLK TSPLNPGTLC LAKYTDGNWY RGIVIEKEPK KVFFVDFGNI YVVTSDDLLP 1080
IPSDAYDVLL LPMQAVRCSL SDIPDHIPEE VVVWFQETIL DKSLKALVVA KDPDGTLIIE 1140
LYGDNIQISA SINKKLGLLS YKDRIRKKES EVLCSTTETL EEKNENMKLP CTEYLSKSVG 1200
YKLPNKEILE ESYKPQINSS YKELKLLQSL TKTNLVTQYQ DSVGNKNSQV FPLTTEKKEE 1260
ISAETPLKTA RVEATLSERK IGDSCDKDLP LKFCEFPQKT IMPGFKTTVY VSHINDLSDF 1320
YVQLIEDEAE ISHLSERLNS VKTRPEYYVG PPLQRGDMIC AVFPEDNLWY RAVIKEQQPN 1380
DLLSVQFIDY GNVSVVHTNK IGRLDLVNAI LPGLCIHCSL QGFEVPDNKN SKKMMHYFSQ 1440
RTSEAAIRCE FVKFQDRWEV ILADEHGIIA DDMISRYALS EKSQVELSTQ VIKSASSKSV 1500
NKSDIDTSVF LNWYNPEKKM IRAYATVIDG PEYFWCQFAD TEKLQCLEVE VQTAGEQVAD 1560
RRNCIPCPYI GDPCIVRYRE DGHYYRALIT NICEDYLVSV RLVDFGNIED CVDPKALWAI 1620
PSELLSVPMQ AFPCCLSGFN ISEGLCSQEG NDYFYEIITE DVLEITILEI RRDVCDIPLA 1680
IVDLKSKGKS INEKMEKYSK TGIKSALPYE NIDSEIKQTL GSYNLDVGLK KLSNKAVQNK 1740
IYMEQQTDEL AEITEKDVNI IGTKPSNFRD PKTDNICEGF ENPCKDKIDT EELEGELECH 1800
LVDKAEFDDK YLITGFNTLL PHANETKEIL ELNSLEVPLS PDDESKEFLE LESIELQNSL 1860
VVDEEKGELS PVPPNVPLSQ ECVTKGAMEL FTLQLPLSCE AEKQPELELP TAQLPLDDKM 1920
DPLSLGVSQK AQESMCTEDM RKSSCVESFD DQRRMSLHLH GADCDPKTQN EMNICEEEFV 1980
EYKNRDAISA LMPLFSEEES SDGSKHNNGL PDHISAQLQN TYTLKAFTVG SKCVVWSSLR 2040
NTWSKCEILE TAEEGTRVLN LSNGMEEIVN PENVWNGIPK LDKSPPEKRG LEVMEI 2096 
Gene Ontology
 GO:0033391; C:chromatoid body; ISS:UniProtKB.
 GO:0005783; C:endoplasmic reticulum; IEA:Compara.
 GO:0043186; C:P granule; IEA:Compara.
 GO:0007281; P:germ cell development; IEA:Compara.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
 GO:0007283; P:spermatogenesis; ISS:UniProtKB. 
Interpro
 IPR002999; Tudor. 
Pfam
 PF00567; TUDOR 
SMART
 SM00333; TUDOR 
PROSITE
 PS50304; TUDOR 
PRINTS