CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033331
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Angio-associated migratory cell protein 
Protein Synonyms/Alias
 Angio-associated, migratory cell protein, isoform CRA_a 
Gene Name
 AAMP 
Gene Synonyms/Alias
 hCG_16292 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
116VTGGEDDKAFVWRLSubiquitination[1]
203DGNTWMWKVPNGDCKubiquitination[2]
210KVPNGDCKTFQGPNCubiquitination[2, 3, 4]
246TIRIWDLKQGSPIHVubiquitination[1, 2, 4, 5, 6, 7, 8]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [6] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [7] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [8] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 435 AA 
Protein Sequence
MESESESGAA ADTPPLETLS FHGDEEIIEV VELDPGPPDP ADDLAQEMED VDFEEEEEEE 60
GNEEGWVLEP QEGVVGSMEG PDDSEVTFAL HSASVFCVSL DPKTNTLAVT GGEDDKAFVW 120
RLSDGELLFE CAGHKDSVTC AGFSHDSTLV ATGDMSGLLK VWQVDTKEEV WSFEAGDLEW 180
MEWHPRAPVL LAGTADGNTW MWKVPNGDCK TFQGPNCPAT CGRVLPDGKR AVVGYEDGTI 240
RIWDLKQGSP IHVLKGTEGH QGPLTCVAAN QDGSLILTGS VDCQAKLVSA TTGKVVGVFR 300
PETVASQPSL GEGEESESNS VESLGFCSVM PLAAVGYLDG TLAIYDLATQ TLRHQCQHQS 360
GIVQLLWEAG TAVVYTCSLD GIVRLWDART GRLLTDYRGH TAEILDFALS KDASLVVTTS 420
GDHKAKVFCV QRPDR 435 
Gene Ontology
  
Interpro
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS