CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016767
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Putative transferase CAF17 homolog, mitochondrial 
Protein Synonyms/Alias
 Iron-sulfur cluster assembly factor homolog 
Gene Name
 Iba57 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
222GDLQDYHKYRYQQGIacetylation[1, 2, 3, 4, 5]
311ATGQAAGKFRAGQGHacetylation[4, 6]
311ATGQAAGKFRAGQGHsuccinylation[6]
Reference
 [1] Mitochondrial acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice.
 Fritz KS, Galligan JJ, Hirschey MD, Verdin E, Petersen DR.
 J Proteome Res. 2012 Mar 2;11(3):1633-43. [PMID: 22309199]
 [2] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [3] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [4] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [5] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [6] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337
Functional Description
 Required for normal heme biosynthesis (By similarity). 
Sequence Annotation
  
Keyword
 Complete proteome; Heme biosynthesis; Mitochondrion; Reference proteome; Transferase; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 358 AA 
Protein Sequence
MAAVALLRGA AVGRRSPAWH WRLSGTASHC LARGFGLLGS NPADGVAWTC FRLDGRALVR 60
VRGPDAAPFL LGLSTNELPL SGPPTGAAQP SARAAYAHFL NVQGRTLYDV ILYGLPECTE 120
GAPSFLLECD SSVLGALQKH LSMYKIRRKV TVEPSPELHV WAVLPCVPQT SETAPLEERV 180
EGTTMLIRDP RTARMGWRLL TQDDGPALVP RGQLGDLQDY HKYRYQQGIP EGVCDLPPGM 240
ALPLESNLVF MNGVSFTKGC YIGQELTART HHTGVIRKRL FPVKLEGPLP ASGVSPGAIV 300
TVTATGQAAG KFRAGQGHVG LALLRSETIK GPLHIKTSES QLVAVTAVVP DWWPTAAK 358 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0004047; F:aminomethyltransferase activity; IEA:InterPro.
 GO:0006546; P:glycine catabolic process; IEA:InterPro.
 GO:0006783; P:heme biosynthetic process; IEA:UniProtKB-KW. 
Interpro
 IPR013977; GCV_T_C.
 IPR006222; GCV_T_N.
 IPR017703; YgfZ/GcvT_CS. 
Pfam
 PF01571; GCV_T
 PF08669; GCV_T_C 
SMART
  
PROSITE
  
PRINTS