| Tag | Content |
|---|
| CPLM ID | CPLM-010435 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Endonuclease III-like protein 1 |
Protein Synonyms/Alias | |
Gene Name | NTHL1 |
Gene Synonyms/Alias | NTH1; OCTS3 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 83 | GEGAEPLKVPVWEPQ | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | Has both an apurinic and/or apyrimidinic endonuclease activity and a DNA N-glycosylase activity. Incises damaged DNA at cytosines, thymines and guanines. Acts on a damaged strand, 5' from the damaged site. Required for the repair of both oxidative DNA damage and spontaneous mutagenic lesions. |
Sequence Annotation | ACT_SITE 220 220 Nucleophile; for N-glycosylase activity.
METAL 290 290 Iron-sulfur (4Fe-4S) (By similarity).
METAL 297 297 Iron-sulfur (4Fe-4S) (By similarity).
METAL 300 300 Iron-sulfur (4Fe-4S) (By similarity).
METAL 306 306 Iron-sulfur (4Fe-4S) (By similarity).
MOD_RES 71 71 Phosphoserine.
MOD_RES 73 73 Phosphoserine. |
Keyword | 4Fe-4S; Complete proteome; DNA damage; DNA repair; Glycosidase; Hydrolase; Iron; Iron-sulfur; Lyase; Metal-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 312 AA |
Protein Sequence | MCSPQESGMT ALSARMLTRS RSLGPGAGPR GCREEPGPLR RREAAAEARK SHSPVKRPRK 60
AQRLRVAYEG SDSEKGEGAE PLKVPVWEPQ DWQQQLVNIR AMRNKKDAPV DHLGTEHCYD 120
SSAPPKVRRY QVLLSLMLSS QTKDQVTAGA MQRLRARGLT VDSILQTDDA TLGKLIYPVG 180
FWRSKVKYIK QTSAILQQHY GGDIPASVAE LVALPGVGPK MAHLAMAVAW GTVSGIAVDT 240
HVHRIANRLR WTKKATKSPE ETRAALEEWL PRELWHEING LLVGFGQQTC LPVHPRCHAC 300
LNQALCPAAQ GL 312 |
Gene Ontology | GO:0005739; C:mitochondrion; IEA:Compara. GO:0005654; C:nucleoplasm; TAS:Reactome. GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. GO:0019104; F:DNA N-glycosylase activity; IDA:UniProtKB. GO:0003906; F:DNA-(apurinic or apyrimidinic site) lyase activity; IDA:UniProtKB. GO:0003690; F:double-stranded DNA binding; IDA:UniProtKB. GO:0004519; F:endonuclease activity; TAS:ProtInc. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0045008; P:depyrimidination; TAS:Reactome. GO:0006296; P:nucleotide-excision repair, DNA incision, 5'-to lesion; IDA:UniProtKB. |
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