UniProt Accession

 CYC_HORSE; P00004 

Genbank Protein ID

  

Genbank Nucleotide ID

  

Protein Name

 Cytochrome c 

Protein Synonyms/Alias

  

Gene Name

 CYCS 

Gene Synonyms/Alias

 CYC 

Created Date

 July 27, 2013 

Organism

 Equus caballus (Horse) 

NCBI Taxa ID

 9796 

Lysine Modification

Position	Peptide	Type	References
6	**MGDVEKGKKIFVQ	acetylation	[1]
8	MGDVEKGKKIFVQKC	acetylation	[1]
9	GDVEKGKKIFVQKCA	acetylation	[1]
14	GKKIFVQKCAQCHTV	acetylation	[1]
23	AQCHTVEKGGKHKTG	acetylation	[1]
26	HTVEKGGKHKTGPNL	acetylation	[1]
28	VEKGGKHKTGPNLHG	acetylation	[2]
40	LHGLFGRKTGQAPGF	acetylation	[1, 2]
54	FTYTDANKNKGITWK	acetylation	[1, 2]
56	YTDANKNKGITWKEE	acetylation	[1]
61	KNKGITWKEETLMEY	acetylation	[1]
73	MEYLENPKKYIPGTK	acetylation	[1, 2]
74	EYLENPKKYIPGTKM	acetylation	[1]
80	KKYIPGTKMIFAGIK	acetylation	[1, 2]
87	KMIFAGIKKKTERED	acetylation	[1, 2]
88	MIFAGIKKKTEREDL	acetylation	[1, 2]
89	IFAGIKKKTEREDLI	acetylation	[1, 2]
100	EDLIAYLKKATNE**	acetylation	[1, 2]
101	DLIAYLKKATNE***	acetylation	[1]

Reference

 [1] Epitope mapping by chemical modification of free and antibody-bound protein antigen.
 Burnens A, Demotz S, Corradin G, Binz H, Bosshard HR.
 Science. 1987 Feb 13;235(4790):780-3. [PMID: 2433768]
 [2] POSTMan (POST-translational modification analysis), a software application for PTM discovery.
 Arntzen MØ, Osland CL, Raa CR, Kopperud R, Døskeland SO, Lewis AE, D'Santos CS.
 Proteomics. 2009 Mar;9(5):1400-6. [PMID: 19253288] 

Functional Description

 Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. 

Sequence Annotation

 METAL 19 19 Iron (heme axial ligand).
 METAL 81 81 Iron (heme axial ligand).
 BINDING 15 15 Heme (covalent).
 BINDING 18 18 Heme (covalent).
 MOD_RES 2 2 N-acetylglycine.
 MOD_RES 49 49 Phosphotyrosine (By similarity).
 MOD_RES 98 98 Phosphotyrosine (By similarity).  

Keyword

 3D-structure; Acetylation; Apoptosis; Complete proteome; Direct protein sequencing; Electron transport; Heme; Iron; Metal-binding; Mitochondrion; Phosphoprotein; Reference proteome; Respiratory chain; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 105 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; ISS:UniProtKB.
 GO:0005758; C:mitochondrial intermembrane space; IEA:UniProtKB-SubCell.
 GO:0070469; C:respiratory chain; IEA:UniProtKB-KW.
 GO:0045155; F:electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity; ISS:UniProtKB.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0006309; P:apoptotic DNA fragmentation; ISS:UniProtKB.
 GO:0022900; P:electron transport chain; IEA:UniProtKB-KW. 

Interpro

 IPR002327; Cyt_c_1A/1B.
 IPR009056; Cyt_c_dom.
 IPR003088; Cyt_c_I. 

Pfam

 PF00034; Cytochrom_C 

SMART

  

PROSITE

 PS51007; CYTC 

PRINTS

 PR00604; CYTCHRMECIAB.