CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012554
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Pumilio domain-containing protein KIAA0020 
Protein Synonyms/Alias
 HBV X-transactivated gene 5 protein; HBV XAg-transactivated protein 5; Minor histocompatibility antigen HA-8; HLA-HA8 
Gene Name
 KIAA0020 
Gene Synonyms/Alias
 XTP5 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
106RSDESAAKKPKWDDFacetylation[1]
107SDESAAKKPKWDDFKacetylation[1]
114KPKWDDFKKKKKELKacetylation[1]
129QSRQLSDKTNYDIVVubiquitination[2]
139YDIVVRAKQMWEILRubiquitination[2]
221YSRNIVKKFLMYGSKubiquitination[2]
228KFLMYGSKPQIAEIIubiquitination[2]
284GNTFQLYKSADHRTLubiquitination[2]
342FFTYAPPKLRSEMIEubiquitination[2]
464EIIEVLQKGDGNAHSubiquitination[2]
591HVGMKNLKSWASVNRubiquitination[2]
619LEVANKVKAALKSLIubiquitination[2]
645GIEILLEKLST****ubiquitination[2]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
 DOMAIN 143 510 PUM-HD.
 REPEAT 165 200 Pumilio 1.
 REPEAT 201 236 Pumilio 2.
 REPEAT 237 273 Pumilio 3.
 REPEAT 350 385 Pumilio 4.
 REPEAT 386 422 Pumilio 5.
 REPEAT 424 460 Pumilio 6.
 REGION 289 297 HA-8.  
Keyword
 Complete proteome; Direct protein sequencing; Nucleus; Polymorphism; Reference proteome; Repeat; RNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 648 AA 
Protein Sequence
MEVKGKKQFT GKSTKTAQEK NRFHKNSDSG SSKTFPTRKV AKEGGPKVTS RNFEKSITKL 60
GKKGVKQFKN KQQGDKSPKN KFQPANKFNK KRKFQPDGRS DESAAKKPKW DDFKKKKKEL 120
KQSRQLSDKT NYDIVVRAKQ MWEILRRKDC DKEKRVKLMS DLQKLIQGKI KTIAFAHDST 180
RVIQCYIQYG NEEQRKQAFE ELRDDLVELS KAKYSRNIVK KFLMYGSKPQ IAEIIRSFKG 240
HVRKMLRHAE ASAIVEYAYN DKAILEQRNM LTEELYGNTF QLYKSADHRT LDKVLEVQPE 300
KLELIMDEMK QILTPMAQKE AVIKHSLVHK VFLDFFTYAP PKLRSEMIEA IREAVVYLAH 360
THDGARVAMH CLWHGTPKDR KVIVKTMKTY VEKVANGQYS HLVLLAAFDC IDDTKLVKQI 420
IISEIISSLP SIVNDKYGRK VLLYLLSPRD PAHTVREIIE VLQKGDGNAH SKKDTEVRRR 480
ELLESISPAL LSYLQEHAQE VVLDKSACVL VSDILGSATG DVQPTMNAIA SLAATGLHPG 540
GKDGELHIAE HPAGHLVLKW LIEQDKKMKE NGREGCFAKT LVEHVGMKNL KSWASVNRGA 600
IILSSLLQSC DLEVANKVKA ALKSLIPTLE KTKSTSKGIE ILLEKLST 648 
Gene Ontology
 GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW. 
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR012959; CPL.
 IPR001313; Pumilio_RNA-bd_rpt. 
Pfam
 PF08144; CPL 
SMART
 SM00025; Pumilio 
PROSITE
 PS50302; PUM
 PS50303; PUM_HD 
PRINTS