UniProt Accession

 SEPT7_HUMAN; Q16181; Q52M76; Q6NX50 

Genbank Protein ID

 S72008; BC067264; BC093640; BC093642 

Genbank Nucleotide ID

 AAB31337.1; AAH67264.2; AAH93640.2; AAH93642.2 

Protein Name

 Septin-7 

Protein Synonyms/Alias

 CDC10 protein homolog 

Gene Name

 SEPT7 

Gene Synonyms/Alias

 CDC10 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
234	TDDEEENKLVKKIKD	ubiquitination	[1]
297	RTHMQDLKDVTNNVH	ubiquitination	[1]
394	KNLEAQHKELEEKRR	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements. 

Sequence Annotation

 NP_BIND 57 64 GTP.
 NP_BIND 195 203 GTP (By similarity).
 BINDING 90 90 GTP (By similarity).
 BINDING 116 116 GTP; via amide nitrogen (By similarity).
 BINDING 250 250 GTP; via amide nitrogen and carbonyl
 BINDING 265 265 GTP (By similarity).
 MOD_RES 2 2 N-acetylserine.
 MOD_RES 30 30 Phosphotyrosine (By similarity).
 MOD_RES 228 228 Phosphothreonine (By similarity).
 MOD_RES 334 334 Phosphoserine.
 MOD_RES 424 424 Phosphoserine.
 MOD_RES 426 426 Phosphothreonine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Cell cycle; Cell division; Cell projection; Centromere; Chromosome; Cilium; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; GTP-binding; Kinetochore; Mitosis; Nucleotide-binding; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 437 AA 

Protein Sequence

Gene Ontology

 GO:0043679; C:axon terminus; IEA:Compara.
 GO:0035085; C:cilium axoneme; ISS:UniProtKB.
 GO:0032154; C:cleavage furrow; IEA:UniProtKB-SubCell.
 GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell.
 GO:0015630; C:microtubule cytoskeleton; IDA:HPA.
 GO:0030496; C:midbody; IEA:UniProtKB-SubCell.
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0031105; C:septin complex; IEA:InterPro.
 GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
 GO:0001725; C:stress fiber; IDA:UniProtKB.
 GO:0045202; C:synapse; IEA:Compara.
 GO:0005525; F:GTP binding; TAS:ProtInc.
 GO:0005198; F:structural molecule activity; TAS:ProtInc.
 GO:0060271; P:cilium morphogenesis; ISS:UniProtKB.
 GO:0000910; P:cytokinesis; TAS:ProtInc.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0051291; P:protein heterooligomerization; IDA:UniProtKB.
 GO:0016476; P:regulation of embryonic cell shape; ISS:UniProtKB. 

Interpro

 IPR000038; Cell_div_GTP-bd.
 IPR027417; P-loop_NTPase.
 IPR016491; Septin.
 IPR008115; Septin7. 

Pfam

 PF00735; Septin 

SMART

  

PROSITE

  

PRINTS

 PR01742; SEPTIN7.